Evidence map›Paper›PMID 38351021›Full record

ArticleMalaria journal2024

A machine learning approach for early identification of patients with severe imported malaria.

Alessandra D'Abramo, Francesco Rinaldi, Serena Vita, Riccardo Mazzieri, Angela Corpolongo, Claudia Palazzolo, Tommaso Ascoli Bartoli, Francesca Faraglia, Maria Letizia Giancola, Enrico Girardi and 1 more

Abstract read
In one paragraph

Article in Malaria journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Balancing innovation and risk: artificial intelligence in travel medicine.Tropical diseases, travel medicine and vaccines · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessandra D'Abramo *National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Francesco Rinaldi *Department of Mathematics "Tullio Levi-Civita", University of Padova, Via Trieste, 63, 35131, Padua, Italy.
Serena VitaNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy. serena.vita@inmi.it.
Riccardo MazzieriDepartment of Information Engineering, University of Padova, Via Giovanni Gradenigo, 6B, 35131, Padua, Italy.
Angela CorpolongoNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Claudia PalazzoloNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Tommaso Ascoli BartoliNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Francesca FaragliaNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Maria Letizia GiancolaNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Enrico GirardiNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Emanuele NicastriNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.

Funding

Ministero della Salute Line1 Ricerca Corrente "Studio dei patogeni ad alto impatto sociale: emergent, da importazione, multiresistenti, negletti"
6 · The paper itself

Abstract

backgroundThe aim of this study is to design ad hoc malaria learning (ML) approaches to predict clinical outcome in all patients with imported malaria and, therefore, to identify the best clinical setting.

methodsThis is a single-centre cross-sectional study, patients with confirmed malaria, consecutively hospitalized to the Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy from January 2007 to December 2020, were recruited. Different ML approaches were used to perform the analysis of this dataset: support vector machines, random forests, feature selection approaches and clustering analysis.

resultsA total of 259 patients with malaria were enrolled, 89.5% patients were male with a median age of 39 y/o. In 78.3% cases, Plasmodium falciparum was found. The patients were classified as severe malaria in 111 cases. From ML analyses, four parameters, AST, platelet count, total bilirubin and parasitaemia, are associated to a negative outcome. Interestingly, two of them, aminotransferase and platelet are not included in the current list of World Health Organization (WHO) criteria for defining severe malaria.

conclusionIn conclusion, the application of ML algorithms as a decision support tool could enable the clinicians to predict the clinical outcome of patients with malaria and consequently to optimize and personalize clinical allocation and treatment.

Indexed as

MalariaMalaria, FalciparumCross-Sectional StudiesFemaleHumansItalyMalePlasmodium falciparumRetrospective StudiesImported malariaMachine learningRisk factorsSevere malaria

Identifiers

PMID38351021
PMCPMC10865572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.