Evidence map›Paper›PMID 38351013›Full record

ReviewRadiation oncology (London, England)2024

Review of brachytherapy clinical trials: a cross-sectional analysis of ClinicalTrials.gov.

David Chen, Rod Parsa, Kabir Chauhan, Jelena Lukovic, Kathy Han, Amandeep Taggar, Srinivas Raman

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiation oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

David ChenPrincess Margaret Cancer Centre, Radiation Medicine Program, Toronto, ON, Canada.
Rod ParsaPrincess Margaret Cancer Centre, Radiation Medicine Program, Toronto, ON, Canada.
Kabir ChauhanPrincess Margaret Cancer Centre, Radiation Medicine Program, Toronto, ON, Canada.
Jelena LukovicPrincess Margaret Cancer Centre, Radiation Medicine Program, Toronto, ON, Canada.
Kathy HanPrincess Margaret Cancer Centre, Radiation Medicine Program, Toronto, ON, Canada.
Amandeep TaggarDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Srinivas RamanPrincess Margaret Cancer Centre, Radiation Medicine Program, Toronto, ON, Canada. Srinivas.Raman@rmp.uhn.ca.
Princess Margaret Cancer Centre · CAUniversity of Toronto · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCharacterizing the landscape of clinical trials including brachytherapy can provide an overview of the current status and research trends which may guide further areas of investigation.

methodWe queried 449,849 clinical trials from the ClinicalTrials.gov registry using brachytherapy-related keywords from 1980 to 2023, yielding 245 multi-arm and 201 single-arm, brachytherapy trials. Multi-arm and single-arm brachytherapy trials were compared using 12 trial protocol elements.

resultsThe number of trials including brachytherapy has increased over time, with over 60% of trials registered in 2010 onwards. The majority of clinical trials were Phase 2 or 3, evaluated both safety and efficacy, and were funded by academic sponsors. The most common tumor sites evaluated in brachytherapy clinical trials include prostate, cervix, liver, endometrium, and breast.

conclusionThere remains continued interest in clinical trials including brachytherapy focused on evaluation of novel delivery systems, treatment planning, and new indications. More brachytherapy clinical trials are needed to define the optimal clinical utilization and advance prospective research in this field.

Indexed as

BrachytherapyClinical Trials as TopicCross-Sectional StudiesFemaleHumansMale

Identifiers

PMID38351013
PMCPMC10863227
OpenAlexW4391784624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.