ArticleBioelectronic medicine2024
A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation.
Article in Bioelectronic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Selective Motor Stimulation of the Pudendal Nerve Using Multi-Contact Cuff Electrodes: A Pre-Clinical Study in Feline and Ovine Models.Neurourology and urodynamics · 2026Article
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Using a single penetrating interfascicular electrode to improve spatial selectivity of an extraneural polymeric cuff array.Bioelectronic medicine · 2025Article
- Selective motor stimulation of the pudendal nerve using multi-contact cuff electrodes: a pre-clinical study in feline and ovine models.bioRxiv : the preprint server for biology · 2025Article
- Bioelectronic medicine: wearable and implantable electronics.Bioelectronic medicine · 2025Article
- Recent Advances in Stimuli-Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants.Bioengineering & translational medicine · 2025Article
- Micro-Coil Neuromodulation at Single-Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Soft, stretchable conductive hydrogels for high-performance electronic implants.Science advances · 2025Article
- Soft-Actuated Cuff Electrodes with Minimal Contact for Bidirectional Peripheral Interfaces.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Multi-Channel Microscale Nerve Cuffs for Spatially Selective Neuromodulation.Micromachines · 2024Article
- High-Porosity Sieve-Type Neural Electrodes for Motor Function Recovery and Nerve Signal Acquisition.Micromachines · 2024Article
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
- Thin-film implants for bioelectronic medicine.MRS bulletin · 2024Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications may arise, namely cuff displacement or nerve compression, due to a poor adaptability to variable nerve shapes and sizes encountered in vivo. Improvements in cuff design, materials, closing mechanism and surgical approach are necessary to overcome these issues.
methodsIn this work, we propose a microfabricated multi-channel silicone-based soft cuff electrode with a novel easy-to-implant and size-adaptable design and evaluate a number of essential features such as nerve-cuff contact, nerve compression, cuff locking stability, long-term integration and stimulation selectivity. We also compared performance to that of standard fixed-size cuffs.
resultsThe belt-like cuff made of 150 μm thick silicone membranes provides a stable and pressure-free conformal contact, independently of nerve size variability, combined with a straightforward implantation procedure. The adaptable design and use of soft materials lead to limited scarring and demyelination after 6-week implantation. In addition, multi-contact designs, ranging from 6 to 16 electrodes, allow for selective stimulation in models of rat and pig sciatic nerve, achieving targeted activation of up to 5 hindlimb muscles.
conclusionThese results suggest a promising alternative to classic fixed-diameter cuffs and may facilitate the adoption of soft, adaptable cuffs in clinical settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.