Evidence map›Paper›PMID 38350986›Full record

ArticleItalian journal of pediatrics2024

Increased bronchiolitis burden and severity after the pandemic: a national multicentric study.

Sergio Ghirardo, Nicola Ullmann, Alessandro Zago, Michele Ghezzi, Marta Minute, Barbara Madini, Enza D'Auria, Cecilia Basile, Francesca Castelletti, Federica Chironi and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sergio GhirardoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, via dell'Istria 65/1, Trieste, Italy. ghirardo.sergio@gmail.com.ORCID http://orcid.org/0000-0002-6329-4208
Nicola UllmannPediatric Pulmonology and Cystic Fibrosis Unit, Respiratory Intermediate Care Unit, Sleep and Long-Term Ventilation Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Alessandro ZagoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, via dell'Istria 65/1, Trieste, Italy.
Michele GhezziDepartment of Pediatrics, Buzzi Children's Hospital, Milan, Italy.
Marta MinuteOspedale Regionale Ca Foncello Treviso, Treviso, Italy.
Barbara MadiniS.C. Pediatria Pneumoinfettivologia Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Enza D'AuriaDepartment of Pediatrics, Buzzi Children's Hospital, Milan, Italy.
Cecilia BasileDepartment of Pediatrics, Buzzi Children's Hospital, Milan, Italy.
Francesca CastellettiDepartment of Pediatrics, Buzzi Children's Hospital, Milan, Italy.
Federica ChironiDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, 20122, Italy.
Agata CapodiferroDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, 20122, Italy.
Beatrice AndrenacciDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy.
Francesco Maria RissoNeonatal Intensive Care Unit, Children's Hospital, ASST Spedali Civili, Brescia, Italy.
Salvatore AversaNeonatal Intensive Care Unit, Children's Hospital, ASST Spedali Civili, Brescia, Italy.
Laura DottaDepartment of Pediatrics and "A. Nocivelli" Institute for Molecular Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.
Antonella CorettiPediatric Pulmonology and Cystic Fibrosis Unit, Respiratory Intermediate Care Unit, Sleep and Long-Term Ventilation Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Anna Chiara VittucciPediatric Pulmonology and Cystic Fibrosis Unit, Respiratory Intermediate Care Unit, Sleep and Long-Term Ventilation Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Raffaele BadolatoDepartment of Pediatrics and "A. Nocivelli" Institute for Molecular Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.
Alessandro AmaddeoInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
Egidio BarbiDepartment of Medicine, Surgery and Health Sciences, University of Trieste, via dell'Istria 65/1, Trieste, Italy.
Renato CutreraPediatric Pulmonology and Cystic Fibrosis Unit, Respiratory Intermediate Care Unit, Sleep and Long-Term Ventilation Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronavirus 2019 (COVID-19) related containment measures led to the disruption of all virus distribution. Bronchiolitis-related hospitalizations shrank during 2020-2021, rebounding to pre-pandemic numbers the following year. This study aims to describe the trend in bronchiolitis-related hospitalization this year, focusing on severity and viral epidemiology.

methodsWe conducted a retrospective investigation collecting clinical records data from all infants hospitalized for bronchiolitis during winter (1st September-31th March) from September 2018 to March 2023 in six Italian hospitals. No trial registration was necessary according to authorization no.9/2014 of the Italian law.

resultsNine hundred fifty-three infants were hospitalized for bronchiolitis this last winter, 563 in 2021-2022, 34 in 2020-2021, 395 in 2019-2020 and 483 in 2018-2019. The mean length of stay was significantly longer this year compared to all previous years (mean 7.2 ± 6 days in 2022-2023), compared to 5.7 ± 4 in 2021-2022, 5.3 ± 4 in 2020-2021, 6.4 ± 5 in 2019-2020 and 5.5 ± 4 in 2018-2019 (p < 0.001), respectively. More patients required mechanical ventilation this winter 38 (4%), compared to 6 (1%) in 2021-2022, 0 in 2020-2021, 11 (2%) in 2019-2020 and 6 (1%) in 2018-2019 (p < 0.05), respectively. High-flow nasal cannula and non-invasive respiratory supports were statistically more common last winter (p = 0.001 or less). RSV prevalence and distribution did not differ this winter, but coinfections were more prevalent 307 (42%), 138 (31%) in 2021-2022, 1 (33%) in 2020-2021, 68 (23%) in 2019-2020, 61 (28%) in 2018-2019 (p = 0.001).

conclusionsThis study shows a growth of nearly 70% in hospitalisations for bronchiolitis, and an increase in invasive respiratory support and coinfections, suggesting a more severe disease course this winter compared to the last five years.

Indexed as

BronchiolitisCoinfectionRespiratory Syncytial Virus InfectionsHospitalizationHumansInfantPandemicsRetrospective StudiesBronchiolitisBronchiolitis severityCoinfectionsCOVID-19 and bronchiolitisPost-phandemic viral epidemiology

Identifiers

PMID38350986
PMCPMC10865582

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.