Evidence map›Paper›PMID 38350930›Full record

ArticleFluids and barriers of the CNS2024

Deep learning segmentation of peri-sinus structures from structural magnetic resonance imaging: validation and normative ranges across the adult lifespan.

Kilian Hett, Colin D McKnight, Melanie Leguizamon, Jennifer S Lindsey, Jarrod J Eisma, Jason Elenberger, Adam J Stark, Alexander K Song, Megan Aumann, Ciaran M Considine and 2 more

Abstract read
In one paragraph

Article in Fluids and barriers of the CNS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. The parasagittal dural space of the human brain.Brain : a journal of neurology · 2025
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kilian HettDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Colin D McKnightDept. of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Melanie LeguizamonDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer S LindseyDept. of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Jarrod J EismaDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jason ElenbergerDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Adam J StarkDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Alexander K SongDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Megan AumannDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ciaran M ConsidineDept. of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Daniel O ClaassenDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Manus J DonahueDept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. mj.donahue@vumc.org.

Funding

MAPPING THE HUMAN CONNECTOME DURING TYPICAL AGINGU01AG052564 · NIA · WASHINGTON UNIVERSITY · PI SALAT, DAVID H, TERPSTRA, MELISSA J · 2016 to 2020
$18.9M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Quantitative Imaging of Brain Glymphatic Function in HumansR01AG062574 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER, DONAHUE, MANUS J · 2020 to 2024
$3.0M
Quantitative imaging of choroid plexus function and neurofluid circulation in Alzheimer's Disease Related DementiaR01AG083159 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Manus J Donahue · 2023 to 2026
$2.3M
Quantitation of Glymphatic Functioning in Sleep and Meditative StatesR01AT011456 · NCCIH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER, DONAHUE, MANUS J · 2021 to 2023
$1.1M
Expanding Mentorship and Neuroimaging Expertise in Patient-Oriented Studies of Brain, Behavior, and Age-Related DementiasK24AG064114 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER · 2020 to 2024
$855k
NCCIH NIH HHS R01 AT011456NIA NIH HHS K24 AG064114NIA NIH HHS R01 AG062574NIA NIH HHS R01 AG083159NIA NIH HHS U01 AG052564NICHD NIH HHS P50 HD103537NIH HHS R01AG062574NIH HHS R01AT011456
6 · The paper itself

Abstract

backgroundPeri-sinus structures such as arachnoid granulations (AG) and the parasagittal dural (PSD) space have gained much recent attention as sites of cerebral spinal fluid (CSF) egress and neuroimmune surveillance. Neurofluid circulation dysfunction may manifest as morphological changes in these structures, however, automated quantification of these structures is not possible and rather characterization often requires exogenous contrast agents and manual delineation.

methodsWe propose a deep learning architecture to automatically delineate the peri-sinus space (e.g., PSD and intravenous AG structures) using two cascaded 3D fully convolutional neural networks applied to submillimeter 3D T

resultsFindings demonstrate that the PSD and AG volumes can be segmented using T

conclusionsA tool that can be applied to quantify PSD and AG volumes from commonly acquired T

Indexed as

Deep LearningLongevityAdolescentAdultAgedAged, 80 and overChildChild, PreschoolHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMiddle AgedNeural Networks, ComputerYoung AdultArachnoid granulationCSF flowGlymphaticMachine learningParasagittal dural space

Identifiers

PMID38350930
PMCPMC10865560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.