Evidence map›Paper›PMID 38350926›Full record

SynthesisBMC pregnancy and childbirth2024

Can single progesterone concentration predict miscarriage in early pregnant women with threatened miscarriage: a systematic review and meta-analysis.

Yi Gong, Tong Jiang, Yang Sun, Guo-Lin Wu, Bu-Wei Han, Ying Shi, Shan Guan, Jian Li

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yi Gong *Beilun District People's Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, China.
Tong Jiang *Beilun District People's Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, China.
Yang SunGuizhou Medical University, Guiyang, China.
Guo-Lin WuBeilun District People's Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, China.
Bu-Wei HanCollege of Pharmacy, Harbin University of Commerce, Harbin, China.
Ying ShiBeilun District People's Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, China.
Shan GuanDepartment of Obstetrics & Gynecology, Affiliated Hospital of Guizhou Medical University, Guiyang, 150000, China. 2576619521@qq.com.
Jian LiDepartment of Obstetrics & Gynecology, Affiliated Hospital of Guizhou Medical University, Guiyang, 150000, China. liamjiam@gmail.com.
Zhejiang University · CNGuiyang Medical University · CNAffiliated Hospital of Guizhou Medical University · CNHarbin University of Commerce · CN

Funding

Science & Technology Department of Guizhou province ZK[2022]-428The Guizhou Health Healthy Committee project gzwkj2021-309The PhD funding in The Affiliated hospital, Guizhou Medical University gyfybsky-2021-24
6 · The paper itself

Abstract

backgroundAbout 25% of pregnant women experience bleeding in the early stage, and half of them eventually progress to pregnancy loss. Progesterone serves as a useful biomarker to predict miscarriage in threatened miscarriage, yet its performance is still debated.

aimTo evaluate the performance of single serum progesterone predicting miscarriage in early pregnant patients with threatened miscarriage.

methodThe online database was searched to yield the literature using the terms of 'Abortion', 'Miscarriage', and 'serum Progesterone', including PubMed, Scopus, Embase, Cochrane library, and China national knowledge infrastructure. Receiver operating characteristic (ROC) curve, likelihood ratio (LLR) and diagnostic odds ratio (DOR) and 95% confidence interval (CI) were computed. Publication bias was assessed by the deeks funnel plot asymmetry test. Subgroup analyses were conducted according to the progesterone level (< 12 ng/mL), recruited location and region, progesterone measurement method, exogenous progesterone supplement and follow up.

resultsIn total, 12 studies were eligible to be included in this study, with sample sizes ranging from 76 to 1087. The included patients' gestational age was between 4 and 12 weeks. No significant publication bias was detected from all included studies. The threshold of progesterone reported ranged from 8 to 30 ng/ml. The synthesized area under the ROC curve (0.85, 95% CI 0.81 to 0.88), positive LLR (6.2, 4.0 to 9.7) and DOR (18, 12 to 27) of single progesterone measurement distinguishing miscarriage were relatively good in early pregnant patients with threatened miscarriage. When the threshold of < 12 ng/mL was adapted, the progesterone provided a higher area under the ROC curve (0.90 vs. 0.78), positive LLR (8.3 vs. 3.8) and DOR (22 vs.12) than its counterpart (12 to 30 ng/mL).

conclusionSingle progesterone measurement can act as a biomarker of miscarriage in early pregnant patients with threatened miscarriage, and it has a better performance when the concentration is <12 ng/mL.

trial registrationPROSPERO (CRD42021255382).

Indexed as

Abortion, ThreatenedBiomarkersProgesteroneAbortion, SpontaneousFemaleHumansPredictive Value of TestsPregnancyPregnancy Trimester, FirstBiomarkersProgesteroneMeta-analysisMiscarriagePredictionSerum progesteroneThreatened miscarriage

Identifiers

PMID38350926
PMCPMC10863102
OpenAlexW4391781199

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.