Evidence map›Paper›PMID 38350861›Full record

ArticleBMC geriatrics2024

Sex steroid and cognitive function among community-dwelling older men with or without vascular risk factors: a cross-sectional study.

Shuning Tang, Limei Huang, Fangting Lin, Xiuqin Chen, Yunhui Wang, Jixiang Xu, Yujie Wang, Junling Gao, Qianyi Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Shuning TangDepartment of Preventive Medicine and Health Education, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 200032, Shanghai, China.
Limei HuangSongjiang Center of Disease Prevention and Control, 201620, Shanghai, China.
Fangting LinDepartment of Preventive Medicine and Health Education, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 200032, Shanghai, China.
Xiuqin ChenSongjiang Center of Disease Prevention and Control, 201620, Shanghai, China.
Yunhui WangSongjiang District Xinqiao Town Community Health Service Center, 201600, Shanghai, China.
Jixiang XuDepartment of Preventive Medicine and Health Education, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 200032, Shanghai, China.
Yujie WangDepartment of Preventive Medicine and Health Education, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 200032, Shanghai, China.
Junling GaoDepartment of Preventive Medicine and Health Education, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 200032, Shanghai, China. jlgao@fudan.edu.cn.
Qianyi XiaoDepartment of Preventive Medicine and Health Education, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 200032, Shanghai, China. xiaoqianyi@fudan.edu.cn.
Fudan University · CNSongjiang District Central Hospital · CNCommunity Health Center · US

Funding

National Natural Science Foundation of China 82173592 to QYX
6 · The paper itself

Abstract

backgroundThe relationship of testosterone and estradiol concentrations with cognitive function among community-dwelling older men was inconclusive. To examine the association of serum testosterone and estradiol concentrations with cognitive function in older men with or without vascular risk factors (VRFs).

methodsThis cross-sectional study consisted of 224 community-dwelling men aged 65-90 years in the Songjiang District of Shanghai, China. Serum testosterone and estradiol were measured by electrochemiluminescence immunoassay. The following five factors were defined as VRFs in this study: obesity, history of hypertension, diabetes, stroke, and coronary heart disease. Multivariable linear regression was used to examine the association of testosterone and estradiol with the Mini-Mental State Examination (MMSE) in participants with or without VRF. Restricted cubic spline (RCS) regression was performed to account for the nonlinearity of these associations.

resultsAn inverted "U" shaped non-linear relationship was found between testosterone concentration and MMSE score in men with one VRF (P overall =.003, non-linear P =.002). Estradiol showed an inverted "U" shaped non-linear relationship with MMSE score independent of VRFs (men without VRF, P overall =.049, non-linear P =.015; men with one VRF, overall P =.007, non-linear P =.003; men with two or more VRFs, overall P =.009, non-linear P =.005).

conclusionIn older men, an optimal level of sex steroid concentration may be beneficial to cognitive function and the VRFs should be considered when interpreting the relationship between sex steroid and cognitive function.

Indexed as

CognitionEstradiolGonadal Steroid HormonesAgedChinaCross-Sectional StudiesHumansIndependent LivingMaleRisk FactorsTestosteroneEstradiolGonadal Steroid HormonesTestosteroneCognitive functionOlder menSex steroidVascular risk factors

Identifiers

PMID38350861
PMCPMC10865607
OpenAlexW4391776335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.