ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Hyaluronidase-Responsive Bactericidal Cryogel for Promoting Healing of Infected Wounds: Inflammatory Attenuation, ROS Scavenging, and Immune Regulation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
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- Tyrosinase Driven-Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomass Hydrogel for Wound Dressings: Design, Functionalization and Application.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Enzyme responsive antimicrobial hyaluronan-nanocellulose hybrid wound dressings for the treatment of infected wounds.Bioactive materials · 2026Article
- Inflammation and wound healing: a comprehensive overview of mechanisms, therapeutic strategies, and translational perspectives.Biomarker research · 2026Review
- Reclaiming the Microbial Battlefield: Adjuvant Strategies to Overcome Antibiotic Resistance.Microorganisms · 2026Review
- Redox-Responsive Tellurium-Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Adaptive hydrogel platforms for infected bone defect repair: microenvironmental responsiveness, osteoimmunomodulation, and regenerative remodeling.Frontiers in bioengineering and biotechnology · 2026Review
- Innovative microneedle-integrated hydrogels: a promising strategy for diabetic foot ulcer management.Frontiers in bioengineering and biotechnology · 2026Review
- Aggregation-Induced Emission Ionic Liquids for Bacterial Imaging, Biofilm Inhibition, and Mixed Bacterial Infection Wound Healing.Chemical & biomedical imaging · 2025Article
- Antimicrobial hydrogel loaded with broccoli exosomes promotes anti-scarring healing of MRSA-infected wounds.Materials today. Bio · 2025Article
- Snake-fangs-bioinspired intelligently-responsive two-stage AIE gen-containing microneedle-based platform for integrated photodynamic infected-wound management and visual therapeutic diagnosis.Bioactive materials · 2025Article
- Dual ROS/pH-responsive mangiferin-loaded smart microneedles for precision therapy of wound infections.Materials today. Bio · 2025Article
- Polysaccharide from Asimina triloba fruits alleviates DSS-induced ulcerative colitis by modulating inflammatory signaling and gut microbiota.NPJ science of food · 2025Article
- Multifunctional NIR-Triggered Nanozyme-Based Microneedles for Synergistic Eradication of MRSA and Enhanced Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Visible-Light-Driven TiOSmall (Weinheim an der Bergstrasse, Germany) · 2025Article
- Copper Ion and Tannic Acid Polyphenol-Metal Scaffold Loaded with Curcumin Promote Skin Wound Healing.ACS omega · 2025Article
- Elastin-like polypeptide and triclosan-modified PCL membrane provides aseptic protection in tissue regeneration.Materials today. Bio · 2025Article
- Multiplexed self-adaptable Janus hydrogels rescue epithelial malfunction to promote complete trachea repair.Nature communications · 2025Article
- Multifunctional microneedle-mediated photothermo-gas-ion synergic therapy accelerates MRSA infacted diabetic wound healing.Materials today. Bio · 2025Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Wounds infected with multidrug-resistant (MDR) bacteria are increasingly threatening public health and challenging clinical treatments because of intensive bacterial colonization, excessive inflammatory responses, and superabundant oxidative stress. To overcome this malignant burden and promote wound healing, a multifunctional cryogel (HA/TA2/KR2) composed of hyaluronic acid (HA), tannic acid (TA), and KR-12 peptides is designed. The cryogel exhibited excellent shape-memory properties, strong absorption performance, and hemostatic capacity. In vitro experiments demonstrated that KR-12 in the cryogel can be responsively released by stimulation with hyaluronidase produced by bacteria, reaching robust antibacterial activity against Escherichia coli (E. coli), MDR Pseudomonas aeruginosa (MDR-PA), and methicillin-resistant Staphylococcus aureus (MRSA) by disrupting bacterial cell membranes. Furthermore, the synergetic effect of KR-12 and TA can efficiently scavenge ROS and decrease expression of pro-inflammatory cytokines (tumor necrosis factor (TNF)-α & interleukin (IL)-6), as well as modulate the macrophage phenotype toward the M2 type. In vivo animal tests indicated that the cryogel can effectively destroy bacteria in the wound and promote healing process via accelerating angiogenesis and re-epithelialization. Proteomic analysis revealed the underlying mechanism by which the cryogel mainly reshaped the infected wound microenvironment by inhibiting the Nuclear factor kappa B (NF-κB) signaling pathway and activating the Janus kinase-Signal transducer and activator of transcription (JAK-STAT6) signaling pathway. Therefore, the HA/TA2/KR2 cryogel is a promising dressing candidate for MDR bacteria-infected wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.