Evidence map›Paper›PMID 38350727›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Molecular Engineering of Electrosprayed Hydrogel Microspheres to Achieve Synergistic Anti-Tumor Chemo-Immunotherapy with ACEA Cargo.

Youming Deng, Jiayang Li, Ran Tao, Ke Zhang, Rong Yang, Zhan Qu, Yu Zhang, Jinjian Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Youming DengDepartment of General Surgery, Xiangya Hospital, International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, Central South University, Changsha, 410008, China.
Jiayang LiResearch Institute of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.
Ran TaoDepartment of General Surgery, Xiangya Hospital, International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, Central South University, Changsha, 410008, China.
Ke ZhangDepartment of General Surgery, Xiangya Hospital, International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, Central South University, Changsha, 410008, China.
Rong YangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Zhan QuDepartment of General Surgery, Xiangya Hospital, International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, Central South University, Changsha, 410008, China.
Yu ZhangDepartment of General Surgery, Xiangya Hospital, International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, Central South University, Changsha, 410008, China.
Jinjian HuangResearch Institute of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China.ORCID 0000-0002-8951-8935
Central South University · CNNanjing General Hospital of Nanjing Military Command · CNShanghai Medical College of Fudan University · CN

Funding

China Postdoctoral Science Foundation 2022M723891China Postdoctoral Science Foundation BX20220393National Natural Science Foundation of China 82300648Natural Science Foundation of Hunan Province 2021JJ40978Natural Science Foundation of Jiangsu Province BK20231091Scientific Research Project of Hunan Provincial Health Commission D202304019647Transverse Project of Xiangya Hospital 20220026
6 · The paper itself

Abstract

Molecular engineering of drug delivering platforms to provide collaborative biological effects with loaded drugs is of great medical significance. Herein, cannabinoid receptor 1 (CB1)- and reactive oxygen species (ROS)-targeting electrosprayed microspheres (MSs) are fabricated by loading with the CB1 agonist arachidonoyl 2'-chloroethylamide (ACEA) and producing ROS in a photoresponsive manner. The synergistic anti-tumor effects of ACEA and ROS released from the MSs are assessed. ACEA inhibits epidermal growth factor receptor signaling and altered tumor microenvironment (TME) by activating CB1 to induce tumor cell death. The MSs are composed of glycidyl methacrylate-conjugated xanthan gum (XGMA) and Fe

Indexed as

Antineoplastic AgentsArachidonic AcidsCannabinoid Receptor AgonistsColorectal NeoplasmsImmunotherapyReceptor, Cannabinoid, CB1Tumor MicroenvironmentCD8-Positive T-LymphocytesCell Line, TumorDrug Delivery SystemsDrug DesignEpoxy CompoundsErbB ReceptorsHumansHydrogelsMethacrylatesAntineoplastic AgentsArachidonic Acidsarachidonyl-2-chloroethylamideCannabinoid Receptor AgonistsEpoxy CompoundsErbB Receptorsglycidyl methacrylateHydrogelsMethacrylatesPolysaccharides, BacterialReactive Oxygen SpeciesReceptor, Cannabinoid, CB1xanthan gumACEAcancerchemo‐immunotherapyelectrosprayed hydrogel microspheresmolecular design

Identifiers

PMID38350727
PMCPMC11077688
OpenAlexW4392784151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.