Evidence map›Paper›PMID 38350724›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Decoupling the Influence of Poly(3,4-Ethylenedioxythiophene)-Collagen Composite Characteristics on Cell Stemness.

Rebecca L Keate, Joshua Tropp, Ruiheng Wu, Anthony J Petty, Guillermo A Ameer, Jonathan Rivnay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Rebecca L KeateDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-3519-0081
Joshua TroppDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-1427-1296
Ruiheng WuSimpson Querrey Institute, Northwestern University, Chicago, IL, 60611, USA.ORCID 0000-0003-2666-6110
Anthony J PettyDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-5831-0314
Guillermo A AmeerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0001-6023-048X
Jonathan RivnayDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-0602-6485
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
Division of Electrical, Communications and Cyber Systems ECCS-2023849IIN NSF DMR-1720139National Science Foundation DMR-1720139NCI NIH HHS P30 CA060553NIGMS NIH HHS T32 GM008449NIGMS NIH HHS T32GM008449Northwestern UniversityOffice of Naval Research Global N00014-20-1-2777ONR YIP SP0056955SHyNE Resource ECCS2025633Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource NSF ECCS-2025633
6 · The paper itself

Abstract

Conductive polymers (CPs) are widely studied for their ability to influence a myriad of tissue systems. While their mixed ionic/electronic conductivity is commonly considered the primary driver of these benefits, the mechanisms by which CPs influence cell fate remain unclear. In this study, CP-biomaterial interactions are investigated using collagen, due to its widespread prevalence throughout the body and in tissue engineering constructs. Collagen is functionalized with both electrostatically and covalently bound derivatives of the CP poly(3,4-ethylenedioxythiophene) (PEDOT) doped via backbone-tethered sulfonate groups, which enable high solubility and loading to the collagen biomatrix. Intrinsically doped scaffolds are compared to those incorporated with a commercially available PEDOT formulation, which is complexed with polyanionic polystyrene sulfonate (PSS). Low loadings of intrinsically doped PEDOT do not increase substrate conductivity compared to collagen alone, enabling separate investigation into CP loading and conductivity. Interestingly, higher PEDOT loading bolsters human mesenchymal stromal (hMSC) cell gene expression of Oct-4 and NANOG, which are key transcription factors regulating cell stemness. Conductive collagen composites with commercial PEDOT:PSS do not significantly affect the expression of these transcription factors in hMSCs. Furthermore, it is demonstrated that PEDOT regulates cellular fate independently from physical changes to the material but directly to the loading of the polymer.

Indexed as

Bridged Bicyclo Compounds, HeterocyclicCollagenPolymersBiocompatible MaterialsElectric ConductivityHumansMesenchymal Stem CellsPolystyrenesTissue EngineeringTissue ScaffoldsBiocompatible MaterialsBridged Bicyclo Compounds, HeterocyclicCollagenpoly(3,4-ethylene dioxythiophene)PolymersPolystyrenespolystyrene sulfonic acidcollagenconductive polymersdopantpluripotencystemness

Identifiers

PMID38350724
PMCPMC11251566
OpenAlexW4392784129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.