Evidence map›Paper›PMID 38350699›Full record

ArticleBMJ case reports2024

Hyperammonemic encephalopathy induced by valproic acid.

Qiuyu M Zhu, Amitosh K Singh, Huai-En Rachel Chang, Sandeep A Konka

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Qiuyu M ZhuInternal Medicine, Kaiser Permanente Mid-Atlantic States, Gaithersburg, Maryland, USA martin.x.zhu@kp.org.ORCID http://orcid.org/0000-0003-2751-7985
Amitosh K SinghInternal Medicine, Kaiser Permanente Mid-Atlantic States, Gaithersburg, Maryland, USA.
Huai-En Rachel ChangInternal Medicine, Kaiser Permanente Mid-Atlantic States, Gaithersburg, Maryland, USA.
Sandeep A KonkaHospital Medicine, Mid-Atlantic Permanente Medical Group, Rockville, Maryland, USA.
Kaiser Permanente · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Valproate (VPA) is broad-spectrum antiepileptic drug. Several adverse reactions including hepatotoxicity, fetal risk and pancreatitis are well known and labelled as boxed warnings in the USA. One adverse reaction that is less well known but clinically significant for its severe morbidity is hyperammonemic encephalopathy. We present a case of woman with hyperammonemic encephalopathy following the initiation of VPA therapy; she had a favourable outcome with discontinuation of the drug and prompt treatment with lactulose and L-carnitine.

Indexed as

Brain DiseasesHyperammonemiaNeurotoxicity SyndromesAnticonvulsantsFemaleHumansPregnancyValproic AcidAnticonvulsantsValproic AcidDrugs: CNS (not psychiatric)Healthcare improvement and patient safetyPsychiatry (drugs and medicines)SafetyUnwanted effects / adverse reactions

Identifiers

PMID38350699
PMCPMC10868277
OpenAlexW4391788353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.