Evidence map›Paper›PMID 38350491›Full record

ReviewNutrition reviews2025

Micronutrient status in children aged 6-59 months with severe wasting and/or nutritional edema: implications for nutritional rehabilitation formulations.

Laura Vresk, Mary Flanagan, Allison I Daniel, Isabel Potani, Celine Bourdon, Carolyn Spiegel-Feld, Mehakpreet K Thind, Amber Farooqui, Catriona Ling, Emiliano Miraglia and 6 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07752628 (Safety Trial of F-60 Among Children Hospitalized With Severe Acute Malnutrition), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07752628 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Safety Trial of F-60 Among Children Hospitalized With Severe Acute Malnutrition

TypeinterventionalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2026 to 2027Enrolled320ConditionsDietary Supplementation, Severe Acute Malnutrition, ChildrenArmsF75 milk feeds, F60 milk feeds
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Laura VreskTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Mary FlanaganTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0009-0001-1820-9545
Allison I DanielTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Isabel PotaniTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-3494-534X
Celine BourdonTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6336-0906
Carolyn Spiegel-FeldTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Mehakpreet K ThindTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Amber FarooquiTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Catriona LingTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Emiliano MiragliaTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Guanlan HuTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Bijun WenTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Stanley ZlotkinDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-6565-7252
Philip JamesEmergency Nutrition Network, Oxford, United Kingdom.
Marie McGrathEmergency Nutrition Network, Oxford, United Kingdom.
Robert H J BandsmaTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Undernutrition remains a global struggle and is associated with almost 45% of deaths in children younger than 5 years. Despite advances in management of severe wasting (though less so for nutritional edema), full and sustained recovery remains elusive. Children with severe wasting and/or nutritional edema (also commonly referred to as severe acute malnutrition and part of the umbrella term "severe malnutrition") continue to have a high mortality rate. This suggests a likely multifactorial etiology that may include micronutrient deficiency. Micronutrients are currently provided in therapeutic foods at levels based on expert opinion, with few supportive studies of high quality having been conducted. This narrative review looks at the knowledge base on micronutrient deficiencies in children aged 6-59 months who have severe wasting and/or nutritional edema, in addition to highlighting areas where further research is warranted (See "Future Directions" section).

Indexed as

EdemaMicronutrientsWasting SyndromeChild, PreschoolHumansInfantNutritional StatusMicronutrientsbiotincalciumcopperfolic acidiodineironkwashiorkormagnesiummarasmusmicronutrient deficiencymicronutrient statusmicronutrient toxicityniacinnutritional edemapantothenic acidpediatricphosphoruspotassiumriboflavinseleniumsevere acute malnutritionSevere malnutritionsevere wastingsodiumtherapeutic feedsthiaminevitamin B12vitamin B6zinc

Identifiers

PMID38350491
PMCPMC11632376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.