Evidence map›Paper›PMID 38350044›Full record

ArticleNeurology2024

Association of EEG Background With Diffusion-Weighted Magnetic Resonance Neuroimaging and Short-Term Outcomes After Pediatric Cardiac Arrest.

Ashley M Bach, Matthew P Kirschen, France W Fung, Nicholas S Abend, Steve Ampah, Antara Mondal, Jimmy W Huh, Shih-Shan L Chen, Ian Yuan, Kathryn Graham and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Guideline
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ashley M BachFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-1960-2979
Matthew P KirschenFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-3585-2687
France W FungFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.ORCID 0000-0001-8448-7423
Nicholas S AbendFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.ORCID 0000-0001-6166-2663
Steve AmpahFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.
Antara MondalFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-1466-6623
Jimmy W HuhFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.
Shih-Shan L ChenFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.
Ian YuanFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.
Kathryn GrahamFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.
Jeffrey I BermanFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.
Arastoo VossoughFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-1346-427X
Alexis TopjianFrom the Department of Neurology (A.M.B., M.P.K., F.W.F., N.S.A.), Departments of Anesthesia and Critical Care Medicine (M.P.K., N.S.A., J.W.H., I.Y., K.G., A.T.), Department of Pediatrics (M.P.K., N.S.A., J.W.H., A.T.), Department of Biomedical and Health Informatics (S.A., A.M.), Department of Neurosurgery (S.-S.L.C.), and Department of Radiology (J.I.B., A.V.), Children's Hospital of Philadelphia, PA.
Norwegian Womens Public Health Association · NO

Funding

Cerebral autoregulation and MRI measures of brain injury after pediatric-post cardiac arrestK23NS116120 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI KIRSCHEN, MATTHEW P · 2021 to 2025
$966k
NINDS NIH HHS K23 NS116120
6 · The paper itself

Abstract

BACKGROUND AND

objectivesEEG and MRI features are independently associated with pediatric cardiac arrest (CA) outcomes, but it is unclear whether their combination improves outcome prediction. We aimed to assess the association of early EEG background category with MRI ischemia after pediatric CA and determine whether addition of MRI ischemia to EEG background features and clinical variables improves short-term outcome prediction.

methodsThis was a single-center retrospective cohort study of pediatric CA with EEG initiated ≤24 hours and MRI obtained ≤7 days of return of spontaneous circulation. Initial EEG background was categorized as normal, slow/disorganized, discontinuous/burst-suppression, or attenuated-featureless. MRI ischemia was defined as percentage of brain tissue with apparent diffusion coefficient (ADC) <650 × 10

resultsWe evaluated 90 individuals. EEG background was normal in 16 (18%), slow/disorganized in 42 (47%), discontinuous/burst-suppressed in 12 (13%), and attenuated-featureless in 20 (22%) individuals. The median percentage of MRI ischemia was 5% (interquartile range 1-18); 32 (36%) individuals had high MRI ischemia burden. Twenty-eight (31%) individuals died, and 58 (64%) had unfavorable neurologic outcome. Worse EEG background category was associated with more MRI ischemia ( DISCUSSION: Early EEG background category was associated with MRI ischemia after pediatric CA. Combining EEG and MRI data yielded higher outcome predictive accuracy than either modality alone. The addition of MRI ischemia to clinical variables and EEG background improved short-term outcome prediction.

Indexed as

Heart ArrestChildDiffusion Magnetic Resonance ImagingElectroencephalographyHumansIschemiaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyNeuroimagingPrognosisRetrospective Studies

Identifiers

PMID38350044
PMCPMC11384654
OpenAlexW4391797182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.