Evidence map›Paper›PMID 38349515›Full record

ArticleMolecular neurobiology2024

Enriched Environment Contributes to the Recovery from Neurotoxin-Induced Parkinson's Disease Pathology.

Daphne Alcalá-Zúniga, Erika Espinoza-Torres, Ranjit Kumar Das, Magaly Vargas, Oscar Maldonado, Omar Benavides, Arvind Manojkumar, Roberto de la Garza, Natalia Davila, Isaac Perez and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Daphne Alcalá-ZúnigaDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Erika Espinoza-TorresDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Ranjit Kumar DasDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Magaly VargasDepartment of Psychological Science, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Oscar MaldonadoInstitute of Neuroscience, University of Texas Rio Grande Valley School of Medicine, Harlingen, TX, USA.
Omar BenavidesDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Arvind ManojkumarDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Roberto de la GarzaDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Natalia DavilaDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Isaac PerezDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Alejandro Hernandez MartinezDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Deepa RoyDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Alejandro López-JuárezDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Masoud M ZareiDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Kelsey A BakerInstitute of Neuroscience, University of Texas Rio Grande Valley School of Medicine, Harlingen, TX, USA.
Mario GilDepartment of Psychological Science, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Hansapani RodrigoSchool of Mathematical and Statistical Sciences, University of Rio Grande Valley, Edinburg, TX, USA.
Gabriel A de ErausquinThe Glenn Biggs Institute of Alzheimer's and Neurodegenerative Disorders, Joe and Teresa Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Upal RoyDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA. upal.roy@utrgv.edu.ORCID http://orcid.org/0000-0002-0325-567X
The University of Texas Rio Grande Valley · USThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have investigated the protective role of EE on dopamine dysregulation and subsequent downregulation of DJ1 protein using in vitro and in vivo models of PD. Our study for the first time demonstrated that DJ1 expression has a direct correlation with dopamine downregulation in PD models and exposure to EE has a significant impact on improving the behavioral changes in PD mice. This research provides evidence that exercise in EE has a positive effect on PD without interfering with the current line of therapy.

Indexed as

Mice, Inbred C57BLParkinson DiseaseAnimalsBehavior, AnimalDopamineDopaminergic NeuronsEnvironmentMaleMiceNeurotoxinsProtein Deglycase DJ-1Recovery of FunctionDopamineNeurotoxinsProtein Deglycase DJ-1Cell modelDJ1DopamineEnriched environmentParkinson’s diseaseSH-SY5YThe mouse model

Identifiers

PMID38349515
PMCPMC11339186
OpenAlexW4391778996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.