ArticleBrain imaging and behavior2024
Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia.
Article in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.Psychological medicine · 2026Article
- Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment.Frontiers in aging neuroscience · 2026Article
- Abnormal Functional Connectivity Pattern of the Reward Circuitry Is Associated with Negative Symptoms and Cognitive Functions in First-Episode Schizophrenia.Psychiatry and clinical psychopharmacology · 2025Article
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9 authors.
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Abstract
The anterior cingulate cortex (ACC) is a heterogeneous region of the brain's limbic system that regulates cognitive and emotional processing, and is frequently implicated in schizophrenia. This study aims to characterize resting-state functional connectivity (rsFC) profiles of three subregions of ACC in patients with first-episode schizophrenia and healthy controls. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were collected from 60 first-episode schizophrenia (FES) patients and 60 healthy controls (HC), and the subgenual ACC (sgACC), pregenual ACC (pgACC), and dorsal ACC (dACC) were selected as seed regions from the newest automated anatomical labeling atlas 3 (AAL3). Seed-based rsFC maps for each ACC subregion were generated and compared between the two groups. The results revealed that compared to the HC group, the FES group showed higher rsFC between the pgACC and bilateral lateral orbitofrontal cortex (lOFC), and lower rsFC between the dACC and right posterior OFC (pOFC), the medial prefrontal gyrus (MPFC), and the precuneus cortex (PCu). These findings point to a selective functional dysconnectivity of pgACC and dACC in schizophrenia and provide more accurate information about the functional role of the ACC in this disorder.
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