Evidence map›Paper›PMID 38349277›Full record

ArticleBiomaterials science2024

ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis.

David A McBride, James S Wang, Wade T Johnson, Nunzio Bottini, Nisarg J Shah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David A McBrideDepartment of NanoEngineering and Chemical Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA. d2mcbrid@ucsd.edu.ORCID http://orcid.org/0000-0001-7695-5178
James S WangDepartment of NanoEngineering and Chemical Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA. d2mcbrid@ucsd.edu.
Wade T JohnsonDepartment of NanoEngineering and Chemical Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA. d2mcbrid@ucsd.edu.
Nunzio BottiniKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Nisarg J ShahDepartment of NanoEngineering and Chemical Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA. d2mcbrid@ucsd.edu.ORCID http://orcid.org/0000-0003-1727-5732
University of California San Diego · USCedars-Sinai Medical Center · US

Funding

Resource-based Center for the study of the joint microenvironment in rheumatology (Overall Application)P30AR073761 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STANFORD, STEPHANIE · 2018 to 2022
$3.9M
Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
Intra-Articular Drug Delivery Modulating Immune Cells in Inflammatory Joint DiseaseR01AR081887 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2023 to 2025
$1.8M
Engineered biomaterials modulating inflammatory T cells in rheumatic arthritisF31AR079921 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCBRIDE, DAVID AMBROSE · 2021 to 2022
$79k
NIAMS NIH HHS F31 AR079921NIAMS NIH HHS P30 AR073761NIAMS NIH HHS R01 AR081887NIAMS NIH HHS T32 AR064194
6 · The paper itself

Abstract

Biomaterial-based agents have been demonstrated to regulate the function of immune cells in models of autoimmunity. However, the complexity of the kinetics of immune cell activation can present a challenge in optimizing the dose and frequency of administration. Here, we report a model of autoreactive T cell activation, which are key drivers in autoimmune inflammatory joint disease. The model is termed a multi-scale Agent-Based, Cell-Driven model of Inflammatory Arthritis (ABCD of IA). Using kinetic rate equations and statistical theory, ABCD of IA simulated the activation and presentation of autoantigens by dendritic cells, interactions with cognate T cells and subsequent T cell proliferation in the lymph node and IA-affected joints. The results, validated with

Indexed as

ArthritisAnimalsAutoantigensCytokinesLymphocyte ActivationMiceReceptors, Antigen, T-CellT-LymphocytesAutoantigensCytokinesReceptors, Antigen, T-Cell

Identifiers

PMID38349277
PMCPMC11757005
OpenAlexW4391776170

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.