ArticleRadiology2024
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8
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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial.Nature cancer · 2026Trial
- Article
- Potentiation of the altered immune microenvironment following RF ablation of murine distant tumors with CTLA-4 immunotherapy.European radiology experimental · 2026Article
- Predicting glioma survival and extracellular matrix remodeling through MRI radiogenomics.Cell reports. Medicine · 2026Article
- Review
- Mechanical Microenvironment in Tumor Immune Evasion: Bidirectional Regulation Between Matrix Stiffness and Immune Cells and Its Therapeutic Implications.International journal of biological sciences · 2026Review
- Overcoming Immune Exclusion in a Murine Model of Cirrhotic Hepatocellular Carcinoma via Cryoablation: Insights from Molecular Extracellular pH Imaging.Research square · 2025Article
- Efficacy and Safety Analysis of Triple Therapy (Pabolizumab+Cryoablation+Renvastinib) for Patients with Unresectable Hepatocellular Carcinoma (uHCC).Archives of Iranian medicine · 2025Article
- Interventional Oncology Meets Immuno-oncology: Combination Therapies for Hepatocellular Carcinoma.Radiology · 2024Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Annabella ShewaregaFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0003-0663-3047
Jessica G SantanaFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0002-4370-5823
David NamFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0002-4650-5691
Antonia BerzFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
Jonathan TeferaFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
Vinzent KahlFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0009-0008-7516-5842
Sandeep K MishraFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0002-1016-0206
Daniel ComanFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0002-6289-0817
James DuncanFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0002-5167-9856
Scott J RobertsFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0001-8473-1721
Axel WetterFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
David C MadoffFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0003-3461-437X
Julius ChapiroFrom the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).ORCID 0000-0002-1984-2246
Yale University · USCharité - Universitätsmedizin Berlin · DEAsklepios Klinik Altona · DE
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MSubnetwork-based Quantitative Imaging Biomarkers for Therapy Assessment in AutismR01NS035193 · NINDS · YALE UNIVERSITY · PI JAMES S DUNCAN, LAWRENCE H. STAIB · 1996 to 2026
$9.2Mq4DE: A Biomarker for Image-Guided, Post-MI Hydrogel TherapyR01HL121226 · NHLBI · YALE UNIVERSITY · PI DUNCAN, JAMES S, O'DONNELL, MATTHEW · 2014 to 2022
$6.3MQuantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver CancerR01CA206180 · NCI · YALE UNIVERSITY · PI CHAPIRO, JULIUS, DUNCAN, JAMES S · 2016 to 2025
$6.1MTraining In Multi-modality Molecular & Translational Cardiovascular ImagingT32HL098069 · NHLBI · YALE UNIVERSITY · PI JAMES S DUNCAN, Georges El Fakhri · 2010 to 2026
$5.2MShort Term Research Training: Students in Health Professional SchoolsT35DK104689 · NIDDK · YALE UNIVERSITY · PI LLOYD G CANTLEY, Sarwat I Chaudhry · 2015 to 2026
$2.6MNCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA206180NHLBI NIH HHS R01 HL121226NHLBI NIH HHS T32 HL098069NIDDK NIH HHS P30 DK034989NIDDK NIH HHS T35 DK104689NINDS NIH HHS R01 NS035193
Abstract
Background Image-guided tumor ablation is the first-line therapy for early-stage hepatocellular carcinoma (HCC), with ongoing investigations into its combination with immunotherapies. Matrix metalloproteinase (MMP) inhibition demonstrates immunomodulatory potential and reduces HCC tumor growth when combined with ablative treatment. Purpose To evaluate the effect of incomplete cryoablation with or without MMP inhibition on the local immune response in residual tumors in a murine HCC model. Materials and Methods Sixty 8- to 10-week-old female BALB/c mice underwent HCC induction with use of orthotopic implantation of syngeneic Tib-75 cells. After 7 days, mice with a single lesion were randomized into treatment groups: (
Indexed as
Carcinoma, HepatocellularCryosurgeryLiver NeoplasmsAnimalsCD8-Positive T-LymphocytesFemaleMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMiceMatrix Metalloproteinase InhibitorsMatrix Metalloproteinases
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