Evidence map›Paper›PMID 38349180›Full record

ArticlemBio2024

Characterization of

Leah M VanOtterloo, Luis A Macias, Matthew J Powers, Jennifer S Brodbelt, M Stephen Trent

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 16 citations in OpenAlex.

  1. A posttranslational modification of fimbriae drives pathogenicity inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Membrane-Focused Strategies AgainstAntibiotics (Basel, Switzerland) · 2026
    Review
  4. New Insights intoPathogens (Basel, Switzerland) · 2026
    Review
  5. Article
  6. A surface-exposed cardiolipin synthase provides an unexpected paradigm for maintaining the Gram-negative outer membrane.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. IntracellularProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Leah M VanOtterlooDepartment of Microbiology, College of Art and Sciences, University of Georgia, Athens, Georgia, USA.ORCID 0009-0008-6302-0902
Luis A MaciasDepartment of Chemistry, University of Texas at Austin, Austin, Texas, USA.
Matthew J PowersDepartment of Microbiology, College of Art and Sciences, University of Georgia, Athens, Georgia, USA.
Jennifer S BrodbeltDepartment of Chemistry, University of Texas at Austin, Austin, Texas, USA.
M Stephen TrentDepartment of Microbiology, College of Art and Sciences, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-6134-1800
University of Georgia · USThe University of Texas at Austin · US

Funding

The Cell Envelope of the Multi-Drug Resistant Pathogen Acinetobacter baumanniiR01AI150098 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2020 to 2026
$3.9M
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological MoleculesR35GM139658 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BRODBELT, JENNIFER S. · 2021 to 2025
$2.9M
Synthesis and transport of outer membrane components across the Gram-negative cell envelopeR01AI176776 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026
$2.5M
Molecular mechanisms required for the maintenance of the gram-negative outer membraneR01AI138576 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2018 to 2022
$2.0M
Movement of Ezrin and CD43 During T Cell SignalingR01AI050098 · NIAID · UNIVERSITY OF CHICAGO · PI BURKHARDT, JANIS K. · 2001 to 2005
$1.9M
NIAID NIH HHS R01 AI050098NIAID NIH HHS R01 AI138576NIAID NIH HHS R01 AI150098NIAID NIH HHS R01 AI176776NIGMS NIH HHS R35 GM139658
6 · The paper itself

Abstract

A fundamental feature of Gram-negative bacteria is their outer membrane that protects the cell against environmental stressors. This defense is predominantly due to its asymmetry, with glycerophospholipids located in the inner leaflet and lipopolysaccharide (LPS) or lipooligosaccharide (LOS) confined to the outer leaflet. LPS consists of a lipid A anchor, a core oligosaccharide, and a distal O-antigen while LOS lacks O-antigen. While LPS/LOS is typically essential for growth, this is not the case for IMPORTANCE:

Indexed as

Acinetobacter baumanniiLipopolysaccharidesO AntigensPeptidoglycanlipid-linked oligosaccharidesLipopolysaccharidesO AntigensPeptidoglycancell envelopecore oligosaccharideKdolipid AlipooligosaccharidelipopolysaccharideLOSLPSouter membrane

Identifiers

PMID38349180
PMCPMC10936431
OpenAlexW4391786700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.