Evidence map›Paper›PMID 38349129›Full record

ArticlemBio2024

Lyssavirus M protein degrades neuronal microtubules by reprogramming mitochondrial metabolism.

Yueming Yuan, An Fang, Haoran Wang, Caiqian Wang, Baokun Sui, Jianqing Zhao, Zhen F Fu, Ming Zhou, Ling Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yueming Yuan *State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
An Fang *State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Haoran WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Caiqian WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Baokun SuiState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Jianqing ZhaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Zhen F FuState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Ming ZhouState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-7012-017X
Ling ZhaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-0569-8105
Huazhong Agricultural University · CN

Funding

MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2662023PY005MOST | National Key Research and Development Program of China (NKPs) 2022YFD1800100
6 · The paper itself

Abstract

Infection with neurotropic viruses may result in changes in host behavior, which are closely associated with degenerative changes in neurons. The lyssavirus genus comprises highly neurotropic viruses, including the rabies virus (RABV), which has been shown to induce degenerative changes in neurons, marked by the self-destruction of axons. The underlying mechanism by which the RABV degrades neuronal cytoskeletal proteins remains incomplete. In this study, we show that infection with RABV or overexpression of its M protein can disrupt mitochondrial metabolism by binding to Slc25a4. This leads to a reduction in NAD

Indexed as

LyssavirusRabiesRabies virusAdenosine TriphosphateAmino AcidsAnimalsDogsMicrotubulesMitochondriaNADNerve DegenerationNeuronsTubulinAdenosine TriphosphateAmino AcidsNADTubulinlyssavirusmitochondria metabolismneuron degeneration

Identifiers

PMID38349129
PMCPMC10936203
OpenAlexW4391786430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.