Evidence map›Paper›PMID 38349126›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.

Tsuyoshi Sakai, Young-Yeon Choo, Shinya Mitsuhashi, Reiko Ikebe, Ann Jeffers, Steven Idell, Torry A Tucker, Mitsuo Ikebe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tsuyoshi SakaiDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.ORCID 0000-0002-2153-0831
Young-Yeon ChooDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.ORCID 0000-0001-5288-1186
Shinya MitsuhashiDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.
Reiko IkebeDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.
Ann JeffersDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.
Steven IdellDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.ORCID 0000-0003-4389-2152
Torry A TuckerDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.ORCID 0000-0002-0823-3234
Mitsuo IkebeDepartment of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, Texas, United States.ORCID 0000-0002-8299-6643
The University of Texas Health Science Center at Tyler · US

Funding

Myocardin in the pathogenesis of pleural remodelingR01HL142853 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI IDELL, STEVEN, IKEBE, MITSUO · 2019 to 2022
$1.9M
Fibrinolytic Proteases, meso-mesenchymal transition and pleural remodelingR01HL130133 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI TUCKER, TORRY ALLE · 2017 to 2021
$1.8M
HHS | National Institutes of Health (NIH) HL142853NHLBI NIH HHS R01 HL130133NHLBI NIH HHS R01 HL142853
6 · The paper itself

Abstract

During the progression of pleural fibrosis, pleural mesothelial cells (PMCs) undergo a phenotype switching process known as mesothelial-mesenchymal transition (MesoMT). During MesoMT, transformed PMCs become myofibroblasts that produce increased extracellular matrix (ECM) proteins, including collagen and fibronectin (FN1) that is critical to develop fibrosis. Here, we studied the mechanism that regulates FN1 expression in myofibroblasts derived from human pleural mesothelial cells (HPMCs). We found that myocardin (Myocd), a transcriptional coactivator of serum response factor (SRF) and a master regulator of smooth muscle and cardiac muscle differentiation, strongly controls FN1 gene expression. Myocd gene silencing markedly inhibited FN1 expression.

Indexed as

FibronectinsNuclear ProteinsSerum Response FactorTrans-ActivatorsCollagenFibrosisHumansMyocardinTranscription FactorsTransforming Growth Factor betaCollagenFibronectinsMyocardinNuclear ProteinsSerum Response FactorTrans-ActivatorsTranscription FactorsTransforming Growth Factor betafibronectinfibrosismyocardinSmad3SRF

Identifiers

PMID38349126
PMCPMC11281794
OpenAlexW4391777526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.