Evidence map›Paper›PMID 38349115›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Hypobaric hypoxia modulated structural characteristics of circulating cell-free DNA in high-altitude pulmonary edema.

Manzoor Ali, Raushni Choudhary, Kanika Singh, Swati Kumari, Rahul Kumar, Brian B Graham, M A Qadar Pasha, Stanzen Rabyang, Tashi Thinlas, Aastha Mishra

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Manzoor AliCardio Respiratory Disease Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0009-0005-9923-2980
Raushni ChoudharyCardio Respiratory Disease Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Kanika SinghCardio Respiratory Disease Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Swati KumariCardio Respiratory Disease Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Rahul KumarDepartment of Medicine, University of California, San Francisco, California, United States.
Brian B GrahamDepartment of Medicine, University of California, San Francisco, California, United States.ORCID 0000-0001-7541-2585
M A Qadar PashaInstitute of Hypoxia Research, Delhi, India.ORCID 0000-0003-4126-6860
Stanzen RabyangDepartment of Medicine, Sonam Norboo Memorial Hospital, Leh, India.
Tashi ThinlasDepartment of Medicine, Sonam Norboo Memorial Hospital, Leh, India.
Aastha MishraCardio Respiratory Disease Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0000-0003-0403-0293
Institute of Genomics and Integrative Biology · INSan Francisco General Hospital · US

Funding

Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
Council of Scientific and Industrial Research, India (CSIR) OLP2302NHLBI NIH HHS R01 HL135872
6 · The paper itself

Abstract

The utility of cell-free (cf) DNA has extended as a surrogate or clinical biomarker for various diseases. However, a more profound and expanded understanding of the diverse cfDNA population and its correlation with physiological phenotypes and environmental factors is imperative for using its full potential. The high-altitude (HA; altitude > 2,500 m above sea level) environment characterized by hypobaric hypoxia offers an observational case-control design to study the differential cfDNA profile in patients with high-altitude pulmonary edema (HAPE) (number of subjects,

Indexed as

Altitude SicknessCell-Free Nucleic AcidsHypertension, PulmonaryPulmonary EdemaAltitudeDNAHumansHypoxiaCell-Free Nucleic AcidsDNAcell-free DNADNA integrity indexhigh-altitude pulmonary edemahypobaric hypoxiaperipheral oxygen saturation

Identifiers

PMID38349115
PMCPMC11905808
OpenAlexW4391777560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.