Evidence map›Paper›PMID 38349046›Full record

ArticleSports health

Dose-Response Effect of Mental Health Diagnoses on Concussion Recovery in Children and Adolescents.

Christina L Master, Daniel J Corwin, Daniele Fedonni, Steven B Ampah, Kaitlyn C Housel, Catherine McDonald, Kristy B Arbogast, Matthew F Grady

Open access · hybridAbstract read
In one paragraph

Article in Sports health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Effect of co-morbid anxiety and depression history on multidomain concussion clinical outcomes and recovery time.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Christina L MasterSports Medicine and Performance Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Daniel J CorwinUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Daniele FedonniCenter for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Steven B AmpahDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Kaitlyn C HouselCenter for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Catherine McDonaldCenter for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania.
Kristy B ArbogastUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Matthew F GradySports Medicine and Performance Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Objective Translational Multi-domain Early Concussion AssessmentR01NS097549 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ARBOGAST, KRISTY, MARGULIES, SUSAN SHEPS · 2017 to 2021
$4.5M
Risk Stratification Using Physiologic Markers and Mobile Health-Facilitated Specialist Management to Improve Outcomes in Pediatric Concussion PatientsK23NS128275 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Daniel Corwin · 2022 to 2026
$1.1M
Trigeminovascular sensitization in post-traumatic headache: electrophysiologic and blood biomarkers in youthK23NS124986 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Carlyn Anne Patterson Gentile · 2022 to 2026
$1.0M
NINDS NIH HHS K23 NS124986NINDS NIH HHS K23 NS128275NINDS NIH HHS R01 NS097549
6 · The paper itself

Abstract

backgroundPre-existing mental health diagnoses may contribute to greater emotional symptom burden and prolonged recovery after concussion. HYPOTHESIS: Youth with pre-existing mental health diagnoses will have greater emotional symptom burden, greater risk for delayed return to exercise, and more prolonged recovery from concussion than those without those diagnoses. STUDY

designProspective cohort. LEVEL OF EVIDENCE: Level 3.

methodsA prospective registry of youth concussion was examined for differences in emotional symptom burden after injury to develop a predictive risk model for prolonged recovery. The impact of individual and total number of pre-existing mental health diagnoses (0, 1, 2, and 3+) was assessed, and multivariable logistic regression was performed to identify factors associated with prolonged recovery.

resultsAmong a cohort of 3105 youth with concussion, those with a history of mental health diagnoses, in a dose-response fashion, had greater postinjury emotional symptom burden (7 emotional symptoms vs 4;

conclusionPre-existing mental health diagnoses are associated with greater postinjury emotional symptom burden and longer concussion recovery in a dose-response fashion. Visiovestibular deficits and delayed return to exercise are also associated with pre-existing mental health diagnoses and prolonged recovery. Boys with prolonged recovery from concussion experience greater emotional symptom burden than girls. CLINICAL RELEVANCE: Addressing pre-existing mental health diagnoses is essential to concussion management. Boys with prolonged recovery from concussion may particularly benefit from interventions to address their higher emotional symptom burden. Interventions, including a home visio-vestibular exercise program and symptom-limited exercise, may contribute to improving time to concussion recovery.

Indexed as

Athletic InjuriesBrain ConcussionPost-Concussion SyndromeAdolescentChildEmotionsFemaleHumansMaleMental Healthanxietyattention-deficit disorderattention-deficit hyperactivity disorderconcussiondepressionvisiovestibular

Identifiers

PMID38349046
PMCPMC10916772
OpenAlexW4391778826

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.