Evidence map›Paper›PMID 38348812›Full record

ArticleJournal of veterinary internal medicine

Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats.

Pak-Kan Tang, Rebecca F Geddes, Yu-Mei Chang, Rosanne E Jepson, Dirk Hendrik Nicolaas van den Broek, Nicola Lötter, Jonathan Elliott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Pak-Kan TangDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, United Kingdom.ORCID https://orcid.org/0000-0002-8244-6131
Rebecca F GeddesDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, United Kingdom.ORCID https://orcid.org/0000-0001-9216-4886
Yu-Mei ChangResearch Support Office, Royal Veterinary College, University of London, London, United Kingdom.
Rosanne E JepsonDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, United Kingdom.
Dirk Hendrik Nicolaas van den BroekDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-1231-7799
Nicola LötterDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, United Kingdom.
Jonathan ElliottDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, United Kingdom.
University of London · GBUniversity of Applied Sciences Utrecht · NL

Funding

Royal Canin
6 · The paper itself

Abstract

backgroundIdentification of nephrocalcinosis in cats with chronic kidney disease (CKD) is of clinical interest but the ability of ultrasonography to detect nephrocalcinosis is uncertain.

objectivesTo compare ultrasonography, micro-computed tomography (μCT) and histopathology for identification of nephrocalcinosis. ANIMALS: Twelve kidneys from 7 euthyroid client-owned cats with CKD.

methodsDescriptive study. Renal ultrasonography was performed ante-mortem for nephrocalcinosis detection. Kidneys were grouped based on nephrocalcinosis: present, suspected, or absent. When cats died, necropsy was performed. Renal tissue was evaluated using μCT for macroscopic nephrocalcinosis, and nephrocalcinosis volume-to-kidney tissue ratio (macro-VN:KT) and sagittal nephrocalcinosis area-to-kidney tissue ratio (macro-AN:KT) were calculated. Each kidney subsequently was bisected longitudinally, formalin-fixed, and paraffin-embedded for microscopic nephrocalcinosis assessment using von Kossa and Alizarin red staining with AN:KT (VK-micro-AN:KT and AR-micro-AN:KT) quantified using ImageJ. Data are presented as median (range). Relationships between macroscopic and microscopic AN:KT were assessed using Spearman's correlation.

resultsNephrocalcinosis by ultrasonography was considered to be absent in 3, suspected in 3, and present in 5 kidneys; 1 kidney had nephrolithiasis with nephrocalcinosis. The macro-VN:KT was 0.001%, 0.001%, and 0.019%, and the macro-AN:KT was 0.08%, 0.30%, and 1.47%, respectively. Histologically, VK-micro-AN:KT was 0.21%, 2.85%, and 4.56%, and AR-micro-AN:KT was 1.73%, 5.82%, and 8.90% for kidneys where ultrasonographic macro-nephrocalcinosis was absent, suspected, or present, respectively. A strong correlation was identified between macroscopic (macro-AN:KT) and microscopic (VK-micro-AN:KT) nephrocalcinosis (r CONCLUSIONS AND CLINICAL IMPORTANCE: Ultrasonographically diagnosed nephrocalcinosis correlates well with macroscopic and microscopic nephrocalcinosis at necropsy despite their separation in time.

Indexed as

Cat DiseasesNephrocalcinosisUltrasonographyX-Ray MicrotomographyAnimalsCatsFemaleKidneyMaleRenal Insufficiency, Chroniccalcificationchronic kidney diseaseCKD‐MBDfelinemineralization

Identifiers

PMID38348812
PMCPMC11099790
OpenAlexW4391786023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.