ArticleJournal of the American Heart Association2024
Rising Cardiac Troponin: A Prognostic Biomarker for Mortality After Acute Ischemic Stroke.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Acute Myocardial Injury in Spontaneous Intracerebral Hemorrhage: A Secondary Observational Analysis of the FAST Trial.Journal of the American Heart Association · 2024Trial
- Association of the C-Reactive Protein-Triglyceride-Glucose Index with Stroke-Heart Syndrome and Clinical Prognosis in Patients Undergoing Endovascular Treatment.Journal of cardiovascular development and disease · 2026Article
- [Association between dynamic elevation of high-sensitivity cardiac troponin T and functional outcomes in patients with acute ischemic stroke].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Article
- A novel nutritional index for predicting stroke-heart syndrome and clinical outcomes after endovascular treatment.Frontiers in nutrition · 2026Article
- FIB-4 Index, Systemic Inflammation, and Troponin Trajectory After Endovascular Thrombectomy in Older Patients with Large-Vessel Occlusion Stroke.Clinical interventions in aging · 2026Article
- Myocardial injury in patients with acute ischemic stroke: Prevalence and types of triggers of myocardial demand ischemia.European stroke journal · 2026Article
- Systemic inflammatory indexes mediate cardiac injury following intracerebral hemorrhage.Frontiers in cardiovascular medicine · 2026Article
- Diagnostic value of cardiovascular biomarkers for cerebral-cardiac syndrome risk in acute ischemic stroke.Frontiers in medicine · 2026Article
- Emerging Biosensor Technologies for Stroke Biomarker Detection: A Comprehensive Overview.Analytical science advances · 2025Review
- Serum Biomarkers in Acute Ischemic Stroke: Clinical Applications and Emerging Insights.Journal of clinical medicine · 2025Review
- The Heart-Brain Axis: Key Concepts in Neurocardiology.Cardiology discovery · 2025Review
- Sympathetic overactivation and catecholamine toxicity: mechanisms and therapeutic strategies for neurogenic heart injury following acute ischemic stroke.Frontiers in cardiovascular medicine · 2025Review
- The Hidden Heart: Exploring Cardiac Damage Post-Stroke: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Early Cardiac Evaluation, Abnormal Test Results, and Associations with Outcomes in Patients with Acute Brain Injury Admitted to a Neurocritical Care Unit.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundElevated cardiac troponin (cTn) is detected in 10% to 30% of patients with acute ischemic stroke (AIS) and correlates with poor functional outcomes. Serial cTn measurements differentiate a dynamic cTn pattern (rise/fall >20%), specific for acute myocardial injury, from elevated but stable cTn levels (nondynamic), typically attributed to chronic cardiac/noncardiac conditions. We investigated if the direction of the cTn change (rising versus falling) affects mortality and outcome. METHODS AND
resultsWe retrospectively screened consecutive patients with AIS admitted to 5 stroke centers for elevated cTn at admission and at least 1 additional cTn measurement within 48 hours. The pattern of cTn was defined as rising if >20% increase from baseline, falling if >20% decrease, or nondynamic if ≤20% change in either direction. Logistic regression analyses were performed to assess the association of cTn patterns and 7-day mortality and unfavorable discharge disposition. Of 3789 patients with AIS screened, 300 were included. Seventy-two had a rising pattern, 66 falling, and 162 nondynamic. In patients with AIS with rising cTn, acute ischemic myocardial infarction was present in 54%, compared with 33% in those with falling cTn (
conclusionsRising cTn is independently associated with increased mortality and unfavorable discharge disposition in patients with AIS.
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