Evidence map›Paper›PMID 38348777›Full record

Observational studyJournal of the American Heart Association2024

Association of Angiotensin II Receptor Type 1 and Endothelin-1 Receptor Type A Agonistic Autoantibodies With Adverse Remodeling and Cardiovascular Events After Acute Myocardial Infarction.

Francesco Tona, Giovanni Civieri, Marta Vadori, Giulia Masiero, Laura Iop, Martina Perazzolo Marra, Valentina Perin, Elisa Cuciz, Annagrazia Cecere, Giacomo Bernava and 5 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Francesco TonaDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0003-4828-7875
Giovanni CivieriDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0002-3076-4787
Marta VadoriDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0002-9763-2383
Giulia MasieroDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0003-4209-6824
Laura IopDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0002-7034-9414
Martina Perazzolo MarraDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0001-7645-6993
Valentina PerinDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.
Elisa CucizDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.
Annagrazia CecereDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0001-5587-1215
Giacomo BernavaDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0001-8033-6409
Donatella TansellaDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.
Nataliia NaumovaDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0002-2515-0502
Simran GrewalPenn State Hershey Medical Center Hershey PA USA.ORCID 0000-0002-0675-1951
Emanuele CozziDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.
Sabino IlicetoDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua Padua Italy.ORCID 0000-0002-3676-8746
University of Padua · ITPenn State Milton S. Hershey Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe left ventricular remodeling (LVR) process has limited the effectiveness of therapies after myocardial infarction. The relationship between autoantibodies activating AT1R-AAs (angiotensin II receptor type 1-AAs) and ETAR-AAs (autoantibodies activating endothelin-1 receptor type A) with myocardial infarction has been described. Among patients with ST-segment-elevation myocardial infarction, we investigated the relationship between these autoantibodies with LVR and subsequent major adverse cardiac events. METHODS AND

resultsIn this prospective observational study, we included 131 patients with ST-segment-elevation myocardial infarction (61±11 years of age, 112 men) treated with primary percutaneous coronary intervention. Within 48 hours of admission, 2-dimensional transthoracic echocardiography was performed, and blood samples were obtained. The seropositive threshold for AT1R-AAs and ETAR-AAs was >10 U/mL. Patients were followed up at 6 months, when repeat transthoracic echocardiography was performed. The primary end points were LVR, defined as a 20% increase in left ventricular end-diastolic volume index, and major adverse cardiac event occurrence at follow-up, defined as cardiac death, nonfatal re-myocardial infarction, and hospitalization for heart failure. Forty-one (31%) patients experienced LVR. The prevalence of AT1R-AAs and ETAR-AAs seropositivity was higher in patients with versus without LVR (39% versus 11%,

conclusionsAT1R-AAs and ETAR-AAs are associated with LVR in patients with ST-segment-elevation myocardial infarction. AT1R-AAs are also significantly associated with recurrent major adverse cardiac events. These initial observations may set the stage for a better pathophysiological understanding of the mechanisms contributing to LVR and ST-segment-elevation myocardial infarction prognosis.

Indexed as

Myocardial InfarctionPercutaneous Coronary InterventionST Elevation Myocardial InfarctionAged, 80 and overEchocardiographyHumansMalePrognosisReceptor, Endothelin AReceptors, AngiotensinVentricular Function, LeftVentricular RemodelingReceptor, Endothelin AReceptors, AngiotensinantibodiesimmunologyprognosisremodelingSTEMI

Identifiers

PMID38348777
PMCPMC11010093
OpenAlexW4391779968

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.