ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Speech patterns during memory recall relates to early tau burden across adulthood.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 15 citations in OpenAlex.
- Semantic memory navigation in mild cognitive impairment: Automated markers with neural and biofluid correlates.NeuroImage · 2026Article
- The Puppy Escape Narrative: Validation of an Openly Available Recall Task for MCI Detection.medRxiv : the preprint server for health sciences · 2026Article
- The myth of digital biomarkers in Alzheimer's disease: how to make them a reality.Current opinion in psychiatry · 2026Review
- Early Detection of Alzheimer's Disease and Related Dementias From Spontaneous Speech Using Foundation Speech and Language Models: Comparative Evaluation.JMIR formative research · 2026Article
- Speech-based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Psychometric modeling of Boston process approach data for dementia prediction in the Framingham Heart Study.Journal of the International Neuropsychological Society : JINS · 2026Article
- Review of Artificial Intelligence for Clinical Use in Alzheimer's Disease and Related Dementias.Seminars in neurology · 2026Review
- Integrating acoustic, prosodic, and phonological features for automatic Alzheimer's detection.Frontiers in aging neuroscience · 2026Article
- Multi-modal data analysis for early detection of alzheimer's disease and related dementias.The journal of prevention of Alzheimer's disease · 2025Article
- Linguistic Markers in Spontaneous Speech: Insights into Subjective Cognitive Decline (Review).Healthcare (Basel, Switzerland) · 2025Review
- Linking silent pause locations in speech to amyloid and tau deposition in cognitively unimpaired individuals.Journal of Alzheimer's disease : JAD · 2025Article
- AI-driven fusion of multimodal data for Alzheimer's disease biomarker assessment.Nature communications · 2025Article
- Automated remote longitudinal neuropsychological testing with the California Cognitive Assessment Battery.The Clinical neuropsychologist · 2025Article
- Alzheimer disease seen through the lens of sex and gender.Nature reviews. Neurology · 2025Review
- Association of the digital clock drawing test with amyloid and tau PET biomarkers in low age risk adults.Scientific reports · 2025Article
- Articulatory precision from connected speech as a marker of cognitive decline in Alzheimer's disease risk-enriched cohorts.Journal of Alzheimer's disease : JAD · 2025Article
- Speech patterns during memory recall relates to early tau burden across adulthood.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
introductionEarly cognitive decline may manifest in subtle differences in speech.
methodsWe examined 238 cognitively unimpaired adults from the Framingham Heart Study (32-75 years) who completed amyloid and tau PET imaging. Speech patterns during delayed recall of a story memory task were quantified via five speech markers, and their associations with global amyloid status and regional tau signal were examined.
resultsTotal utterance time, number of between-utterance pauses, speech rate, and percentage of unique words significantly correlated with delayed recall score although the shared variance was low (2%-15%). Delayed recall score was not significantly different between β-amyoid-positive (Aβ+) and -negative (Aβ-) groups and was not associated with regional tau signal. However, longer and more between-utterance pauses, and slower speech rate were associated with increased tau signal across medial temporal and early neocortical regions. DISCUSSION: Subtle speech changes during memory recall may reflect cognitive impairment associated with early Alzheimer's disease pathology. HIGHLIGHTS: Speech during delayed memory recall relates to tau PET signal across adulthood. Delayed memory recall score was not associated with tau PET signal. Speech shows greater sensitivity to detecting subtle cognitive changes associated with early tau accumulation. Our cohort spans adulthood, while most PET imaging studies focus on older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.