Evidence map›Paper›PMID 38348472›Full record

ArticleJournal of the American Chemical Society2024

Cucurbit[8]uril Binds Nonterminal Dipeptide Sites with High Affinity and Induces a Type II β-Turn.

Paolo Suating, Lauren B Kimberly, Marc B Ewe, Sarah L Chang, John M Fontenot, Prakash R Sultane, Christopher W Bielawski, Daniel A Decato, Orion B Berryman, Alexander B Taylor and 1 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paolo SuatingDepartment of Chemistry, Trinity University, 1 Trinity Place, San Antonio, Texas 78212, United States.ORCID 0000-0002-6030-1441
Lauren B KimberlyDepartment of Chemistry, Trinity University, 1 Trinity Place, San Antonio, Texas 78212, United States.
Marc B EweDepartment of Chemistry, Trinity University, 1 Trinity Place, San Antonio, Texas 78212, United States.ORCID 0009-0003-0402-0842
Sarah L ChangDepartment of Chemistry, Trinity University, 1 Trinity Place, San Antonio, Texas 78212, United States.
John M FontenotDepartment of Chemistry, Trinity University, 1 Trinity Place, San Antonio, Texas 78212, United States.
Prakash R SultaneCenter for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS) and Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.ORCID 0000-0001-9862-7589
Christopher W BielawskiCenter for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS) and Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Daniel A DecatoDepartment of Chemistry and Biochemistry, University of Montana, Missoula, Montana 59812, United States.
Orion B BerrymanDepartment of Chemistry and Biochemistry, University of Montana, Missoula, Montana 59812, United States.ORCID 0000-0002-0324-484X
Alexander B TaylorDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, 8300 Floyd Curl Drive, San Antonio, Texas 78229, United States.ORCID 0000-0003-3517-6033
Adam R UrbachDepartment of Chemistry, Trinity University, 1 Trinity Place, San Antonio, Texas 78212, United States.ORCID 0000-0003-3426-4760

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
Minimal Protein Affinity TagsR15GM141708 · NIGMS · TRINITY UNIVERSITY · PI URBACH, ADAM ROBERT · 2021 to 2022
$528k
Upgrade of a Core Laboratory Macromolecular X-ray Diffraction SystemS10OD030374 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI TAYLOR, ALEXANDER B · 2021 to 2021
$439k
Supramolecular Strategies for the Controlled Release of Protein DrugsR15GM126511 · NIGMS · TRINITY UNIVERSITY · PI URBACH, ADAM ROBERT · 2017 to 2017
$400k
NCI NIH HHS P30 CA054174NIGMS NIH HHS R15 GM126511NIGMS NIH HHS R15 GM141708NIH HHS S10 OD030374
6 · The paper itself

Abstract

In an effort to target polypeptides at nonterminal sites, we screened the binding of the synthetic receptor cucurbit[8]uril (Q8) to a small library of tetrapeptides, each containing a nonterminal dipeptide binding site. The resulting leads were characterized in detail using a combination of isothermal titration calorimetry,

Indexed as

Receptors, ArtificialBinding SitesCrystallography, X-RayDipeptidesPeptidesDipeptidesPeptidesReceptors, Artificial

Identifiers

PMID38348472
PMCPMC13651102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.