Evidence map›Paper›PMID 38348408›Full record

ArticleFrontiers in genetics2023

Risk and protection of different rare protein-coding variants of complement component C4A in age-related macular degeneration.

Johanna M Seddon, Dikha De, William Casazza, Shun-Yun Cheng, Claudio Punzo, Mark Daly, Danlei Zhou, Samantha L Coss, John P Atkinson, Chack-Yung Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Johanna M SeddonDepartment of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Dikha DeDepartment of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
William CasazzaDepartment of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Shun-Yun ChengDepartment of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Claudio PunzoDepartment of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Mark DalyBroad Institute of MIT and Harvard, Cambridge, MA, United States.
Danlei ZhouAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Samantha L CossAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
John P AtkinsonDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO, United States.
Chack-Yung YuAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
University of Massachusetts Chan Medical School · USNationwide Children's Hospital · USBroad Institute · USWashington University in St. Louis · US

Funding

Large Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7M
ETIOLOGIC STUDIES OF AGE-RELATED MACULAR DEGENERATIONR01EY011309 · NEI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SEDDON, JOHANNA M · 2003 to 2017
$9.3M
Rare Genetic Variation in Macular DegenerationR01EY028602 · NEI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SEDDON, JOHANNA M · 2018 to 2022
$3.2M
Complement in Human Lupus: Deficiencies, Profiles and ComplicationsR01AR073311 · NIAMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BIRMINGHAM, DANIEL J, YU, CHACK Y · 2018 to 2022
$2.1M
NEI NIH HHS R01 EY011309NEI NIH HHS R01 EY028602NHGRI NIH HHS U54 HG003079NIAMS NIH HHS R01 AR073311
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

age-related macular degenerationC4A, C4Bcomplement proteinscomplement systemgenetic associationstargeted sequencing

Identifiers

PMID38348408
PMCPMC10859408
OpenAlexW4391321239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.