Evidence map›Paper›PMID 38348040›Full record

ArticleFrontiers in immunology2024

Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions.

Luca Schelle, João Vasco Côrte-Real, Sharmeen Fayyaz, Augusto Del Pozo Ben, Margarita Shnipova, Moritz Petersen, Rishikesh Lotke, Bhavna Menon, Dana Matzek, Lena Pfaff and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 4 countries.

Luca Schelle *Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
João Vasco Côrte-Real *Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Sharmeen FayyazInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Augusto Del Pozo BenMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Margarita ShnipovaMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Moritz PetersenInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Rishikesh LotkeInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Bhavna MenonMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Dana MatzekBiomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany.
Lena PfaffBiomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany.
Ana PinheiroCIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal.
João Pedro MarquesCIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal.
José Melo-FerreiraCIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal.
Bastian PopperBiomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany.
Pedro José EstevesCIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal.
Daniel SauterInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Joana AbrantesCIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal.
Hanna-Mari BaldaufMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Ludwig-Maximilians-Universität München · DEInstitute of Medical Microbiology and Hygiene · DEUniversidade do Porto · PTCooperativa de Ensino Superior Politécnico e Universitário · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases, and their expression can be partially induced by interferons (IFNs). GBPs are involved in the cell-autonomous innate immune response against bacterial, parasitic and viral infections. Evolutionary studies have shown that GBPs exhibit a pattern of gene gain and loss events, indicative for the birth-and-death model of evolution. Most species harbor large

Indexed as

LagomorphaAnimalsCarrier ProteinsGTP-Binding ProteinsHumansImmunity, InnateInterferonsMiceRabbitsCarrier ProteinsGTP-Binding ProteinsInterferonsantiviral proteinscross-species conservationevolutionGBPinnate immunitylagomorphsOryctolagus cuniculus

Identifiers

PMID38348040
PMCPMC10859415
OpenAlexW4391320773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.