Mass Spectrometry of Putrescine, Spermidine, and Spermine Covalently Attached to

Lawrence M Schopfer, Benjamin Girardo, Oksana Lockridge, Marilynn A Larson

Open access · goldAbstract read

In one paragraph

Article in Biochemistry research international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Polyamination with spermidine enhances pathogenic tau conformations while reducing filamentous aggregate formation in vitro.The Biochemical journal · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lawrence M SchopferEppley Institute, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-1785-9247

Benjamin GirardoPathology, Microbiology and Immunology Department, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0009-0003-9050-5802

Oksana LockridgeEppley Institute, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-8345-3640

Marilynn A LarsonPathology, Microbiology and Immunology Department, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-0633-0313

University of Nebraska Medical Center · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026

$55.0M

NCI NIH HHS P30 CA036727

6 · The paper itself

Abstract

Bacterial and mammalian cells are rich in putrescine, spermidine, and spermine. Polyamines are required for optimum fitness, but the biological function of these small aliphatic compounds has only been partially revealed. Known functions of polyamines include interaction with nucleic acids that alters gene expression and with proteins that modulate activity. Although polyamines can be incorporated into proteins, very few naturally occurring polyaminated proteins have been identified, which is due in part to the difficulty in detecting these adducts. In the current study, bovine albumin and the recombinant universal stress protein from

Identifiers

PMID38347948

DOI10.1155/2024/7120208

PMCPMC10861277

OpenAlexW4392734933

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.