Evidence map›Paper›PMID 38347655›Full record

ArticleAlzheimer's research & therapy2024

The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study.

Jie Wu, Zhenxu Xiao, Mengjing Wang, Wanqing Wu, Xiaoxi Ma, Xiaoniu Liang, Li Zheng, Saineng Ding, Jianfeng Luo, Yang Cao and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Circulating Biomarkers for the Early Diagnosis of Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  14. Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Real-world utility of plasma GFAP and NfL in early-onset AD and FTD.Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Jie WuInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Zhenxu XiaoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Mengjing WangNational Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Wanqing WuInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoxi MaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoniu LiangInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Li ZhengInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Saineng DingInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jianfeng LuoDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Yang CaoClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, 70182, Örebro, Sweden.
Zhen HongInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jing ChenNational Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Qianhua ZhaoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. qianhuazhao@fudan.edu.cn.
Ding DingInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Huashan Hospital · CNFudan University · CNÖrebro University · SE

Funding

National Natural Science Foundation of China 82071200National Natural Science Foundation of China 82173599National Science and Technology Major Project SQ2021AAA010157Shanghai Municipal Science and Technology Major Project 2018SHZDZX01 and ZJ LAB
6 · The paper itself

Abstract

backgroundThe blood-based biomarkers are approaching the clinical practice of Alzheimer's disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to characterize the impact of renal function on AD markers.

methodsPlasma phospho-tau181 (P-tau181), and neurofilament light (NfL) were assayed via the Simoa HD-X platform in 1189 dementia-free participants from the Shanghai Aging Study (SAS). The estimated glomerular filter rate (eGFR) was calculated. The association between renal function and blood NfL, P-tau181 was analyzed. An analysis of interactions between various demographic and comorbid factors and eGFR was conducted.

resultsThe eGFR levels were negatively associated with plasma concentrations of NfL and P-tau181 (B = - 0.19, 95% CI - 0.224 to - 0.156, P < 0.001; B = - 0.009, 95% CI - 0.013 to -0.005, P < 0.001, respectively). After adjusting for demographic characteristics and comorbid diseases, eGFR remained significantly correlated with plasma NfL (B = - 0.010, 95% CI - 0.133 to - 0.068, P < 0.001), but not with P-tau181 (B = - 0.003, 95% CI - 0.007 to 0.001, P = 0.194). A significant interaction between age and eGFR was found for plasma NfL (P

conclusionsConsidering renal function and age is crucial when interpreting AD biomarkers in the general aging population.

Indexed as

Alzheimer DiseaseAscorbic AcidIntermediate FilamentsAgedAgingAmyloid beta-PeptidesBiomarkersChinaHumansKidneyNeurofilament Proteinstau ProteinsAmyloid beta-PeptidesAscorbic AcidBiomarkersMAPT protein, humanneurofilament protein LNeurofilament Proteinstau ProteinsComorbid conditionsGlomerular filter rateNeurofilament lightPhospho-tau181Renal function

Identifiers

PMID38347655
PMCPMC10860286
OpenAlexW4391746730

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.