ArticleBreast cancer research : BCR2024
MRI-based tumor shrinkage patterns after early neoadjuvant therapy in breast cancer: correlation with molecular subtypes and pathological response after therapy.
Article in Breast cancer research : BCR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Oncological outcomes following extreme oncoplastic breast conserving surgery (eOPBCS) for locally advanced breast cancer (LABC): A systematic review and meta-analysis.Breast (Edinburgh, Scotland) · 2025Pooled it
- Margin status after breast-conserving surgery for breast cancer in the Netherlands from 2009 to 2022.BJS open · 2026Article
- Optimizing abbreviated breast MRI protocols for the early assessment of neoadjuvant chemotherapy response in breast cancer.Quantitative imaging in medicine and surgery · 2026Article
- Ultrasound-based shrinkage patterns at mid-neoadjuvant chemotherapy for predicting pathological complete response in invasive breast cancer.Frontiers in oncology · 2026Article
- Tumor shrinkage patterns and optimal timing of response assessment during neoadjuvant therapy for breast cancer: a study based on multiparametric MRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Preoperative Breast MRI and Histopathology in Breast Cancer: Concordance, Challenges and Emerging Role of CEM and mpMRI.Diagnostics (Basel, Switzerland) · 2025Review
- Alteration of Hyaluronic Acid Metabolism in Tumor Microenvironment Can Modulate DNA Repair Gene Expression: Therapeutic Potential for Triple-Negative Breast Cancer.International journal of molecular sciences · 2025Article
- Comparative analysis of preoperative contrast-enhanced cone beam breast CT (CE-CBBCT) and MRI for differentiating pathological complete response from minimal residual disease in breast cancer.BMC medical imaging · 2025Article
- Effect of Curcuma Longa Extract to Granzyme Expression and Tumor Mass Diameter of Mammary Adenocarcinoma with Chemotherapy Adriamycin Cyclophosphamide: An Animal Study in Rats.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- An ultrasound-based model for predicting the response to neoadjuvant chemotherapy in early stage triple negative breast cancer patients.BMC medical imaging · 2025Article
- Article
- Tumor Morphology for Prediction of Poor Responses Early in Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter Retrospective Study.Tomography (Ann Arbor, Mich.) · 2024Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMRI-based tumor shrinkage patterns (TSP) after neoadjuvant therapy (NAT) have been associated with pathological response. However, the understanding of TSP after early NAT remains limited. We aimed to analyze the relationship between TSP after early NAT and pathological response after therapy in different molecular subtypes.
methodsWe prospectively enrolled participants with invasive ductal breast cancers who received NAT and performed pretreatment DCE-MRI from September 2020 to August 2022. Early-stage MRIs were performed after the first (1st-MRI) and/or second (2nd-MRI) cycle of NAT. Tumor shrinkage patterns were categorized into four groups: concentric shrinkage, diffuse decrease (DD), decrease of intensity only (DIO), and stable disease (SD). Logistic regression analysis was performed to identify independent variables associated with pathologic complete response (pCR), and stratified analysis according to tumor hormone receptor (HR)/human epidermal growth factor receptor 2 (HER2) disease subtype.
results344 participants (mean age: 50 years, 113/345 [33%] pCR) with 345 tumors (1 bilateral) had evaluable 1st-MRI or 2nd-MRI to comprise the primary analysis cohort, of which 244 participants with 245 tumors had evaluable 1st-MRI (82/245 [33%] pCR) and 206 participants with 207 tumors had evaluable 2nd-MRI (69/207 [33%] pCR) to comprise the 1st- and 2nd-timepoint subgroup analysis cohorts, respectively. In the primary analysis, multivariate analysis showed that early DD pattern (OR = 12.08; 95% CI 3.34-43.75; p < 0.001) predicted pCR independently of the change in tumor size (OR = 1.37; 95% CI 0.94-2.01; p = 0.106) in HR
conclusionThe diffuse decrease pattern in HR
trial registrationTrial registration at https://www.chictr.org.cn/ . REGISTRATION NUMBER: ChiCTR2000038578, registered September 24, 2020.
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