Evidence map›Paper›PMID 38347618›Full record

ArticleGenome biology2024

SSBlazer: a genome-wide nucleotide-resolution model for predicting single-strand break sites.

Sheng Xu, Junkang Wei, Siqi Sun, Jizhou Zhang, Ting-Fung Chan, Yu Li

Abstract read
In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sheng Xu *Department of Computer Science and Engineering, The Chinese University of Hong Kong, 100871, Hong Kong SAR, China.
Junkang Wei *Department of Computer Science and Engineering, The Chinese University of Hong Kong, 100871, Hong Kong SAR, China. weijk@link.cuhk.edu.hk.
Siqi SunResearch Institute of Intelligent Complex Systems, Fudan University, 220 Handan Rd, Shanghai, 200437, China.
Jizhou ZhangSchool of Life Sciences, The Chinese University of Hong Kong, 100871, Hong Kong SAR, China.
Ting-Fung ChanSchool of Life Sciences, The Chinese University of Hong Kong, 100871, Hong Kong SAR, China.
Yu LiDepartment of Computer Science and Engineering, The Chinese University of Hong Kong, 100871, Hong Kong SAR, China. liyu@cse.cuhk.edu.hk.

Funding

Chinese University of Hong Kong 4937025, 4937026, 5501517, 5501329Innovation and Technology Commission of the Hong Kong Special Administrative Region GHP/065/21SZResearch Grants Council of the Hong Kong Special Administrative Region CUHK 24204023
6 · The paper itself

Abstract

Single-strand breaks are the major DNA damage in the genome and serve a crucial role in various biological processes. To reveal the significance of single-strand breaks, multiple sequencing-based single-strand break detection methods have been developed, which are costly and unfeasible for large-scale analysis. Hence, we propose SSBlazer, an explainable and scalable deep learning framework for single-strand break site prediction at the nucleotide level. SSBlazer is a lightweight model with robust generalization capabilities across various species and is capable of numerous unexplored SSB-related applications.

Indexed as

DNA DamageNucleotidesDNA RepairNucleotidesGenome instabilityNucleotide-resolution modelSingle-strand break

Identifiers

PMID38347618
PMCPMC10863285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.