ArticleRadiation oncology (London, England)2024
Interfractional variation in whole-breast VMAT irradiation: a dosimetric study with complementary SGRT and CBCT patient setup.
Article in Radiation oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 8 citations in OpenAlex.
- Surface-guided radiation therapy combined with real-time position management-guided deep inspiratory breath-hold radiotherapy for left breast cancer.BMC cancer · 2026Trial
- Evaluation of registration accuracy using short-arc cone-beam computed tomography for image-guided radiotherapy in breast cancer.Journal of applied clinical medical physics · 2026Article
- The impact of orthogonal image-guided frequency on positioning error correction and dose in postoperative radiotherapy for breast cancer.BMC cancer · 2026Article
- Scaling Surface-Guided Radiation Therapy to Larger Lung Cancer Cohorts: Frameless Immobilization and Enhanced Setup Accuracy.Life (Basel, Switzerland) · 2026Article
- Dosimetric effects of internal margin, auto flash, and virtual bolus in VMAT-based whole-breast radiotherapy under motion variations.Journal of applied clinical medical physics · 2026Article
- Beyond the snapshot: continuous optical surface monitoring reveals non-linear temporal dynamics and postural stability window in free-breathing breast radiotherapy.Frontiers in oncology · 2026Article
- Evaluation of the accuracy of a surface-guided radiotherapy system for patient positioning in radiotherapy of breast cancer.Physics and imaging in radiation oncology · 2026Article
- Validation of in vivo dose using EPID combined with fan-beam CT guidance in post-breast-conserving radiotherapy for early-stage breast cancer.BMC cancer · 2025Article
- Is intensive training with a time interval between instruction and planning CT necessary for deep inspiration breath-hold radiotherapy in breast cancer?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Surface-Guided Radiation Therapy (SGRT) for Pediatric Oncology: An Analysis of Inter- and Intra-fraction Motion Variability and PTV Margins.Technology in cancer research & treatmentArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dosimetric effect of setup uncertainty and tissue deformations in left-sided whole-breast irradiation with complementary surface-guided radiotherapy (SGRT) and cone-beam computed tomography (CBCT) setup was evaluated.
methodTreatment courses of 40.05 Gy prescribed dose in 15 fractions were simulated for 29 patients by calculating the dose on deformed CT images, that were based on daily CBCT images, and deforming and accumulating the dose onto the planning CT image. Variability in clinical target volume (CTV) position and shape was assessed as the 95% Hausdorff distance (HD95) between the planning CTV and deformed CTV structures. DVH metrics were evaluated between the planned and simulated cumulative dose distributions using two treatment techniques: tangential volumetric modulated arc therapy (tVMAT) and conventional 3D-conformal radiotherapy (3D-CRT).
resultsBased on the HD95 values, the variations in CTV shape and position were enclosed by the 5 mm CTV-PTV margin in 85% of treatment fractions using complementary CBCT and SGRT setup. A residual error of 8.6 mm was observed between the initial SGRT setup and CBCT setup. The median CTV V95% coverage was 98.1% (range 93.1-99.8%) with tVMAT and 98.2% (range 84.5-99.7%) with 3D-CRT techniques with CBCT setup. With the initial SGRT-only setup, the corresponding coverages were 96.3% (range 92.6-99.4%) and 96.6% (range 84.2-99.4%), respectively. However, a considerable bias in vertical residual error between initial SGRT setup and CBCT setup was observed. Clinically relevant changes between the planned and cumulative doses to organs-at-risk (OARs) were not observed.
conclusionsThe CTV-to-PTV margin should not be reduced below 5 mm even with daily CBCT setup. Both tVMAT and 3D-CRT techniques were robust in terms of dose coverage to the target and OARs. Based on the shifts between setup methods, CBCT setup is recommended as a complementary method with SGRT.
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