Evidence map›Paper›PMID 38347529›Full record

ArticleAnnals of clinical microbiology and antimicrobials2024

Molecular characterization of extensively drug-resistant hypervirulent Pseudomonas aeruginosa isolates in China.

Jun Li, Mengli Tang, Zhaojun Liu, Yuhan Wei, Fengjun Xia, Yubing Xia, Yongmei Hu, Haichen Wang, Mingxiang Zou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jun LiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Mengli TangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhaojun LiuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yuhan WeiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Fengjun XiaDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yubing XiaDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yongmei HuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Haichen WangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Mingxiang ZouDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. zoumingxiang@csu.edu.cn.
Central South University · CNXiangya Hospital Central South University · CN

Funding

Natural Science Foundation of Hunan Province 2022JJ70084Natural Science Foundation of Hunan Province 2023JJ30900Science Foundation of Hunan Health Commission in Hunan province 202111000066
6 · The paper itself

Abstract

backgroundRecently, extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) isolates have been increasingly detected and posed great challenges to clinical anti-infection treatments. However, little is known about extensively resistant hypervirulent P. aeruginosa (XDR-hvPA). In this study, we investigate its epidemiological characteristics and provide important basis for preventing its dissemination.

methodsClinical XDR-PA isolates were collected from January 2018 to January 2023 and identified using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry; antibiotic susceptibility testing was performed by broth microdilution method, and minimum inhibitory concentrations (MICs) were evaluated. Virulence was evaluated using the Galleria mellonella infection model; molecular characteristics, including resistance genes, virulence genes, and homology, were determined using whole-genome sequencing.

resultsA total of 77 XDR-PA strains were collected; 47/77 strains were XDR-hvPA. Patients aged > 60 years showed a significantly higher detection rate of XDR-hvPA than of XDR-non-hvPA. Among the 47 XDR-hvPA strains, 24 strains carried a carbapenemase gene, including bla

conclusionsThe clinical detection rate of XDR-hvPA is unexpectedly high, particularly in patients aged > 60 years, who are seemingly more susceptible to contracting this infection. Clonal transmission of XDR-hvPA carrying bla

Indexed as

Anti-Bacterial AgentsPseudomonas InfectionsAgedBacterial Proteinsbeta-LactamasesChinaDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsPseudomonas aeruginosaSerogroupAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesClinical featuresDrug resistance mechanismExtensive drug resistanceMolecular epidemiologyPseudomonas aeruginosaVirulence

Identifiers

PMID38347529
PMCPMC10863134
OpenAlexW4391743205

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.