Trial reportJournal of anesthesia2024
Comparison of remimazolam-based and propofol-based total intravenous anesthesia on hemodynamics during anesthesia induction in patients undergoing transcatheter aortic valve replacement: a randomized controlled trial.
Trial report in Journal of anesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The delirium dichotomy of remimazolam: a differential risk profile for emergence delirium versus postoperative delirium in surgical patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Remimazolam vs propofol for postoperative delirium in adults undergoing general anesthesia: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Comparing subjective quality of recovery between remimazolam- and propofol-based total intravenous anesthesia for surgical procedures: a meta-analysis.Systematic reviews · 2024Pooled it
- Pooled it
- Safety and efficacy of remimazolam compared with propofol for general anesthesia during cold knife conization: a single-center, randomized controlled trial.BMC anesthesiology · 2025Trial
- Remimazolam for Zephyr Endobronchial Valve Placement in a Severe Chronic Obstructive Pulmonary Disease Patient: A Case Report.Clinical case reports · 2026Article
- Incidence and predictors of activities of daily living decline after transcatheter aortic valve implantation.Journal of anesthesia · 2026Article
- Effects of remimazolam and propofol on parasympathetic activity during general anesthesia induction in patients with severe aortic stenosis: a randomized controlled trial utilizing high-frequency variability index.Journal of clinical monitoring and computing · 2026Article
- Relationship between age and blood pressure reduction during induction of general anesthesia with remimazolam: an observational study.Journal of anesthesia · 2026Article
- Vasopressor requirements and hemodynamic stability during anesthesia using remimazolam and sevoflurane in patients undergoing minimally invasive aortic valve replacement surgery: a prospective randomized controlled study.Journal of thoracic disease · 2026Article
- Comparison of intraoperative hemodynamic parameters between propofol- and remimazolam-based total intravenous anesthesia in patients undergoing robotic gynecologic surgery: a randomized controlled trial protocol.Frontiers in pharmacology · 2026Article
- Reply to Fernández et al. Comment on "Goudra et al. Anesthesia for Bronchoscopy-An Update.Journal of clinical medicine · 2025Article
- A retrospective analysis of hemodynamic stability in TAVR and TTVR under general anesthesia: implications for sedation in TTVR.BMC anesthesiology · 2025Article
- Enhancing acute normovolemic hemodilution in cardiac surgery: the role of remimazolam and hemodynamic stability.Journal of anesthesia · 2025Article
- Remimazolam Use in Awake Craniotomy for Patient with Morbid Obesity and Recurrent Glioma.The American journal of case reports · 2025Article
- Remimazolam in the perioperative setting: an answer in search of an ideal question.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Article
- Using Remimazolam to Generate Hemodynamically Stable Burst Suppression: A Case Report and Literature Review.Case reports in anesthesiology · 2025Article
- Safety of Remimazolam in Vulnerable Populations.Drug design, development and therapy · 2025Review
- Reply to the letter.Journal of anesthesia · 2024Article
- Is remimazolam superior to propofol in TAVR procedure?Journal of anesthesia · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to compare the hemodynamic effects of remimazolam- and propofol-based total intravenous anesthesia in patients who underwent transcatheter aortic valve replacement.
methodsThis was a single-center, single-blind, randomized controlled trial set at Nara Medical University, Kashihara, Japan. We included 36 patients aged ≥ 20 years scheduled to undergo elective transfemoral transcatheter aortic valve replacement (TAVR) under general anesthesia. The participants were randomly assigned to the remimazolam and propofol groups (n = 18 each). Remimazolam- or propofol-based total intravenous anesthesia was initiated at 12 mg/kg/min or 2.5 mcg/mL via target-controlled infusion, respectively, along with remifentanil. After confirming the loss of consciousness, the administration rate was adjusted using electroencephalographic monitoring. The primary outcome was the rate of arterial hypotension, defined as a mean arterial pressure < 60 mmHg, from anesthesia induction until the beginning of the surgical incision. The total doses of ephedrine and phenylephrine were also assessed.
resultsDuring anesthesia induction, the arterial hypotension rates were 11.9% and 21.6% in the remimazolam and propofol groups, respectively (P = 0.01). The total dose of ephedrine was higher in the propofol group (14.4 mg) than in the remimazolam group (1.6 mg) (P < 0.001); however, the total dose of phenylephrine was not significantly different between the two groups (propofol 0.31 mg vs. remimazolam: 0.17 mg, P = 0.10).
conclusionRemimazolam-based total intravenous anesthesia resulted in a lower hypotension rate than propofol-based total intravenous anesthesia during induction in patients undergoing TAVR. Remimazolam-based total intravenous anesthesia can be used safely during anesthetic induction in patients with severe aortic stenosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.