Evidence map›Paper›PMID 38347201›Full record

ArticleNature neuroscience2024

Independent inhibitory control mechanisms for aggressive motivation and action.

Tomohito Minakuchi, Eartha Mae Guthman, Preeta Acharya, Justin Hinson, Weston Fleming, Ilana B Witten, Stefan N Oline, Annegret L Falkner

Abstract read
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Serotonin modulates nucleus accumbens circuits to suppress aggression.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tomohito MinakuchiPrinceton Neuroscience Institute, Princeton, NJ, USA.ORCID http://orcid.org/0009-0008-9013-3275
Eartha Mae GuthmanPrinceton Neuroscience Institute, Princeton, NJ, USA.
Preeta AcharyaPrinceton Neuroscience Institute, Princeton, NJ, USA.
Justin HinsonPrinceton Neuroscience Institute, Princeton, NJ, USA.
Weston FlemingPrinceton Neuroscience Institute, Princeton, NJ, USA.
Ilana B WittenPrinceton Neuroscience Institute, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-0548-2160
Stefan N OlinePrinceton Neuroscience Institute, Princeton, NJ, USA.
Annegret L FalknerPrinceton Neuroscience Institute, Princeton, NJ, USA. afalkner@princeton.edu.ORCID http://orcid.org/0000-0001-9756-7887

Funding

Mapping experience-dependent change in a circuit for aggressionR01MH126035 · NIMH · PRINCETON UNIVERSITY · PI FALKNER, ANNEGRET LEA · 2021 to 2025
$2.6M
Generating pro-resilient states through individualized circuit read-write therapeuticsDP2MH126375 · NIMH · PRINCETON UNIVERSITY · PI FALKNER, ANNEGRET LEA · 2020 to 2020
$2.4M
Inhibitory Control of Hypothalamic Circuit for AggressionR00MH109674 · NIMH · PRINCETON UNIVERSITY · PI FALKNER, ANNEGRET LEA · 2018 to 2020
$743k
Inhibitory control of a hypothalamic circuit for aggressionK99MH109674 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FALKNER, ANNEGRET LEA · 2016 to 2017
$198k
Experience dependent regulation of subcortical neural circuits for aggressionF32MH126562 · NIMH · PRINCETON UNIVERSITY · PI GUTHMAN, EARTHA MAE · 2022 to 2024
$169k
Heiwa Nakajima Foundation (HNF) NANIMH NIH HHS DP2 MH126375NIMH NIH HHS F32 MH126562NIMH NIH HHS K99 MH109674NIMH NIH HHS R00 MH109674NIMH NIH HHS R01 MH126035U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) DP2MH126375U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F32MH126562U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R00MH109674U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH126035
6 · The paper itself

Abstract

Social behaviors often consist of a motivational phase followed by action. Here we show that neurons in the ventromedial hypothalamus ventrolateral area (VMHvl) of mice encode the temporal sequence of aggressive motivation to action. The VMHvl receives local inhibitory input (VMHvl shell) and long-range input from the medial preoptic area (MPO) with functional coupling to neurons with specific temporal profiles. Encoding models reveal that during aggression, VMHvl shell

Indexed as

AggressionMotivationAnimalsHypothalamusMiceNeuronsSocial Behavior

Identifiers

PMID38347201
PMCPMC12716102

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.