Evidence map›Paper›PMID 38347104›Full record

ArticleNature microbiology2024

A conserved interdomain microbial network underpins cadaver decomposition despite environmental variables.

Zachary M Burcham, Aeriel D Belk, Bridget B McGivern, Amina Bouslimani, Parsa Ghadermazi, Cameron Martino, Liat Shenhav, Anru R Zhang, Pixu Shi, Alexandra Emmons and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Zachary M BurchamDepartment of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
Aeriel D BelkDepartment of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
Bridget B McGivernDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0001-9023-0018
Amina BouslimaniCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Parsa GhadermaziDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, USA.
Cameron MartinoDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Liat ShenhavCenter for Studies in Physics and Biology, Rockefeller University, New York, NY, USA.
Anru R ZhangDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
Pixu ShiDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
Alexandra EmmonsDepartment of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
Heather L DeelGraduate Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
Zhenjiang Zech XuSchool of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.ORCID http://orcid.org/0000-0003-1080-024X
Victoria NiecieckiDepartment of Animal Sciences, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0002-1891-5909
Qiyun ZhuDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-3568-6271
Michael ShafferDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.
Morgan PanitchpakdiCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Kelly C WeldonCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Kalen CantrellDepartment of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6262-1668
Asa Ben-HurDepartment of Computer Science, Colorado State University, Fort Collins, CO, USA.
Sasha C ReedU.S. Geological Survey, Southwest Biological Science Center, Moab, UT, USA.
Greg C HumphryDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Gail AckermannDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Daniel McDonaldDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Siu Hung Joshua ChanDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0002-7707-656X
Melissa ConnorForensic Investigation Research Station, Colorado Mesa University, Grand Junction, CO, USA.
Derek BoydForensic Anthropology Center, Department of Anthropology, University of Tennessee, Knoxville, TN, USA.ORCID http://orcid.org/0000-0003-1444-0536
Jake SmithForensic Anthropology Center, Department of Anthropology, University of Tennessee, Knoxville, TN, USA.
Jenna M S WatsonForensic Anthropology Center, Department of Anthropology, University of Tennessee, Knoxville, TN, USA.
Giovanna VidoliForensic Anthropology Center, Department of Anthropology, University of Tennessee, Knoxville, TN, USA.
Dawnie SteadmanForensic Anthropology Center, Department of Anthropology, University of Tennessee, Knoxville, TN, USA.ORCID http://orcid.org/0000-0003-0812-0739
Aaron M LynneDepartment of Biological Sciences, Sam Houston State University, Huntsville, TX, USA.
Sibyl BucheliDepartment of Biological Sciences, Sam Houston State University, Huntsville, TX, USA.
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-3003-1030
Kelly C WrightonDepartment of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.
David O CarterLaboratory of Forensic Taphonomy, Forensic Sciences Unit, School of Natural Sciences and Mathematics, Chaminade University of Honolulu, Honolulu, HI, USA.ORCID http://orcid.org/0000-0003-1885-5237
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-0975-9019
Jessica L MetcalfDepartment of Animal Sciences, Colorado State University, Fort Collins, CO, USA. jessica.metcalf@colostate.edu.ORCID http://orcid.org/0000-0001-8374-8046

Funding

Predoctoral Training in Quantitative Cell & Molecular BiologyT32GM132057 · NIGMS · COLORADO STATE UNIVERSITY · PI Karen Marie Dobos, Brian Munsky · 2019 to 2026
$2.9M
Isolation of a cervical cancer tumor suppressor geneI01BX000194 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI SRIVATSAN, ERI S · 2009 to 2012
–
BLRD VA I01 BX000194NIGMS NIH HHS T32 GM132057
6 · The paper itself

Abstract

Microbial breakdown of organic matter is one of the most important processes on Earth, yet the controls of decomposition are poorly understood. Here we track 36 terrestrial human cadavers in three locations and show that a phylogenetically distinct, interdomain microbial network assembles during decomposition despite selection effects of location, climate and season. We generated a metagenome-assembled genome library from cadaver-associated soils and integrated it with metabolomics data to identify links between taxonomy and function. This universal network of microbial decomposers is characterized by cross-feeding to metabolize labile decomposition products. The key bacterial and fungal decomposers are rare across non-decomposition environments and appear unique to the breakdown of terrestrial decaying flesh, including humans, swine, mice and cattle, with insects as likely important vectors for dispersal. The observed lockstep of microbial interactions further underlies a robust microbial forensic tool with the potential to aid predictions of the time since death.

Indexed as

Microbial ConsortiaSoil MicrobiologyAnimalsBacteriaCadaverCattleHumansMetagenomeMiceSwine

Identifiers

PMID38347104
PMCPMC10914610

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.