Evidence map›Paper›PMID 38346727›Full record

ArticleThe Journal of veterinary medical science2024

Pharmacokinetics/pharmacodynamics cut-off determination for fosfomycin using Monte Carlo simulation in healthy horses.

Taisuke Kuroda, Yohei Minamijima, Hidekazu Niwa, Hiroshi Mita, Norihisa Tamura, Kentaro Fukuda, Pierre-Louis Toutain, Minoru Ohta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Taisuke KurodaClinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Yohei MinamijimaDrug Analysis Department, Laboratory of Racing Chemistry, Tochigi, Japan.
Hidekazu NiwaMicrobiology Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Hiroshi MitaClinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Norihisa TamuraClinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Kentaro FukudaClinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Pierre-Louis ToutainComparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom.
Minoru OhtaClinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Japan Racing Association · JPLaboratory of Racing Chemistry · JPRoyal Veterinary College · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fosfomycin (FOM) is an approved veterinary medicinal product for large animals in Japan, but Clinical breakpoint (CBP) for antimicrobial susceptibility test (AST) is not defined for animals. This study aimed at conducting a pharmacokinetics/pharmacodynamics (PK/PD) analysis to determine the PK/PD cutoff for the CBP in horses. Drug concentrations following single intravenous administration (IV) of 20 mg/kg body weight (BW) FOM in nine horses were measured using liquid chromatography/mass spectrometry. The data were modelled using a nonlinear mixed-effects model, followed by Monte Carlo simulations. A 90% probability of target attainment for a PK/PD target of the ratio of Area Under the free plasma concentration-time curve divided by the minimal inhibitory concentration (MIC) >24 hr was set as PK/PD cut-off. The PK/PD cutoff for FOM 20 mg/kg BW q12 hr IV was estimated with the MIC value of ≤16.0 mg/L, and this regimen was considered effective against E. coli (MIC

Indexed as

Escherichia coli InfectionsFosfomycinHorse DiseasesAnimalsAnti-Bacterial AgentsEscherichia coliHorsesHumansMicrobial Sensitivity TestsMonte Carlo MethodAnti-Bacterial AgentsFosfomycinantimicrobial susceptibility testingEscherichia colifosfomycinhorsepharmacokinetics/pharmacodynamics (PK/PD) cutoff

Identifiers

PMID38346727
PMCPMC11061577
OpenAlexW4391732934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.