Evidence map›Paper›PMID 38346466›Full record

ArticlePhotodiagnosis and photodynamic therapy2024

Three-dimensional printing of the human lung pleural cavity model for PDT malignant mesothelioma.

Dennis Sourvanos, Hongjing Sun, Timothy C Zhu, Andreea Dimofte, Brook Byrd, Theresa M Busch, Keith A Cengel, Rodrigo Neiva, Joseph P Fiorellini

Open access · goldAbstract read
In one paragraph

Article in Photodiagnosis and photodynamic therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dennis SourvanosDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, PA, USA; Center for Innovation and Precision Dentistry (CiPD), School of Dental Medicine, School of Engineering, University of Pennsylvania, PA, USA. Electronic address: DSourvan@upenn.edu.
Hongjing SunDepartment of Radiation Oncology, Perelman Center for Advanced Medicine, University of Pennsylvania, PA, USA.
Timothy C ZhuDepartment of Radiation Oncology, Perelman Center for Advanced Medicine, University of Pennsylvania, PA, USA.
Andreea DimofteDepartment of Radiation Oncology, Perelman Center for Advanced Medicine, University of Pennsylvania, PA, USA.
Brook ByrdDepartment of Radiation Oncology, Perelman Center for Advanced Medicine, University of Pennsylvania, PA, USA.
Theresa M BuschDepartment of Radiation Oncology, Perelman Center for Advanced Medicine, University of Pennsylvania, PA, USA.
Keith A CengelDepartment of Radiation Oncology, Perelman Center for Advanced Medicine, University of Pennsylvania, PA, USA.
Rodrigo NeivaDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, PA, USA.
Joseph P FiorelliniDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, PA, USA.
University of Pennsylvania · USCenter for Innovation · US

Funding

Optimizing singlet oxygen dosimetry for photodynamic therapy (PDT)R01EB032821 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI HADFIELD, ROBERT HUGH, ZHU, TIMOTHY C. · 2022 to 2025
$2.4M
In situ PEDSy and light delivery platform for Intracavitory Photodynamic TherapyR01EB028778 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI POTASEK, MARY, ZHU, TIMOTHY C. · 2020 to 2023
$2.2M
Advanced Training at the Interface of Engineering and Oral-Craniofacial SciencesT90DE030854 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI Hyun Koo, Kathleen J Stebe · 2021 to 2026
$1.4M
NIBIB NIH HHS R01 EB028778NIBIB NIH HHS R01 EB032821NIDCR NIH HHS T90 DE030854
6 · The paper itself

Abstract

objectiveThe primary aim was to investigate emerging 3D printing and optical acquisition technologies to refine and enhance photodynamic therapy (PDT) dosimetry in the management of malignant pleural mesothelioma (MPM). MATERIALS AND

methodsA rigorous digital reconstruction of the pleural lung cavity was conducted utilizing 3D printing and optical scanning methodologies. These reconstructions were systematically assessed against CT-derived data to ascertain their accuracy in representing critical anatomic features and post-resection topographical variations.

resultsThe resulting reconstructions excelled in their anatomical precision, proving instrumental translation for precise dosimetry calculations for PDT. Validation against CT data confirmed the utility of these models not only for enhancing therapeutic planning but also as critical tools for educational and calibration purposes.

conclusionThe research outlined a successful protocol for the precise calculation of light distribution within the complex environment of the pleural cavity, marking a substantive advance in the application of PDT for MPM. This work holds significant promise for individualizing patient care, minimizing collateral radiation exposure, and improving the overall efficiency of MPM treatments.

Indexed as

Lung NeoplasmsMesothelioma, MalignantPhotochemotherapyPrinting, Three-DimensionalHumansMesotheliomaPhotosensitizing AgentsPleural CavityPleural NeoplasmsTomography, X-Ray ComputedPhotosensitizing Agents3D printingDosimetryFluenceMedical dosimetryMesotheliomaPhotodynamic therapyPrecision medicine

Identifiers

PMID38346466
PMCPMC11968026
OpenAlexW4391715552

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.