Evidence map›Paper›PMID 38346421›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2024

Lower self-reported ART adherence among adolescents in boarding schools compared to day schools.

Brenda Wandika, Florence Nyapara, Calvince Aballa, Barbra A Richardson, Dalton Wamalwa, Grace John-Stewart, Irene Inwani, Irene Njuguna

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Brenda Wandika. Medical Research, Kenyatta National Hospital, Nairobi, Kenya.
Florence Nyapara. Medical Research, Kenyatta National Hospital, Nairobi, Kenya.
Calvince Aballa. Medical Research, Kenyatta National Hospital, Nairobi, Kenya.
Barbra A Richardson. Global Health, University of Washington, Seattle, USA.
Dalton Wamalwa. Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Grace John-Stewart. Global Health, University of Washington, Seattle, USA.
Irene Inwani. Medical Research, Kenyatta National Hospital, Nairobi, Kenya.
Irene Njuguna. Medical Research, Kenyatta National Hospital, Nairobi, Kenya.
Kenyatta National Hospital · KESeattle University · USUniversity of Nairobi · KEUniversity of Washington · US

Funding

Promoting Diversity, Equity, and Inclusivity in Research Training to Optimize HIV Prevention and TreatmentD43TW009580 · FIC · UNIVERSITY OF WASHINGTON · PI CAREY FARQUHAR, John Kinuthia · 2013 to 2026
$4.8M
Understanding the role of schools in supporting HIV treatment outcomes among HIV infected adolescentsK43TW011422 · FIC · KENYATTA NATIONAL HOSPITAL · PI NJUGUNA, IRENE NYAMBURA · 2020 to 2024
$603k
FIC NIH HHS 1K43TW011422-01AFIC NIH HHS D43 TW009580FIC NIH HHS K43 TW011422
6 · The paper itself

Abstract

introductionAdolescents living with HIV (ALH) have poorer adherence to antiretroviral therapy (ART) than adults. Many ALH in sub-Saharan Africa (SSA) are enrolled in boarding schools where stigma is pervasive and may impact adherence.

methodsWe collected sociodemographic data, school information, medical history, and viral load (VL) data from ALH age 14-19 in 25 HIV clinics in 3 counties in Kenya. Using generalized estimating equations, we compared ART adherence in ALH attending day and boarding schools.

resultsOf 880 ALH, 798 (91%) were enrolled in school, of whom 189 (24%) were in boarding schools. Of those in school, median age was 16 (IQR: 15, 18), 55% were female, 78% had a parent as a primary caregiver, and 74% were on DTG-based ART. Median age at ART initiation was 6 years (IQR 3, 10).Overall, 227 (29%) ALH self-reported missing ART when school was in session (40% in boarding and 25% in day school). After adjusting for sociodemographic and HIV care characteristics, ALH in boarding schools were significantly more likely to self-report missing ART than those in day schools (adjusted Prevalence Ratio (aPR): 1.47, 95% CI 1.18, 1.83, p=0.001). Among 194 ALH, only 60% had undetectable (<20 copies/ml) HIV viral load (62% day schools and 51% boarding schools)(p=0.097).

conclusionALH had high self-reported non-adherence overall, with worse adherence among those in boarding schools. Schools remain a critical untapped resource for improving ALH outcomes.

Indexed as

Anti-HIV AgentsHIV InfectionsMedication AdherenceSchoolsAdolescentFemaleHumansKenyaMaleSelf ReportViral LoadYoung AdultAnti-HIV Agents

Identifiers

PMID38346421
PMCPMC11317543
OpenAlexW4392729983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.