Evidence map›Paper›PMID 38346197›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation.

Arnaud N Molin, Romain Contentin, Marco Angelozzi, Anirudha Karvande, Ranjan Kc, Abdul Haseeb, Chantal Voskamp, Charles de Charleroy, Véronique Lefebvre

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Arnaud N Molin *Department of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0003-0520-2800
Romain Contentin *Department of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0001-5917-7298
Marco AngelozziDepartment of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Anirudha KarvandeDepartment of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0003-0102-9860
Ranjan KcDepartment of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0002-2582-401X
Abdul HaseebDepartment of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Chantal VoskampDepartment of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Charles de CharleroyDepartment of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Véronique LefebvreDepartment of Surgery, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0003-2225-8267
Children's Hospital of Philadelphia · US

Funding

Roles of SOX8 and SOX9 in Adult Articular CartilageR01AR072649 · NIAMS · CHILDREN'S HOSP OF PHILADELPHIA · PI LEFEBVRE, VERONIQUE M · 2018 to 2022
$2.9M
Transcriptional control of growth plate chondrocytesR01AR080062 · NIAMS · CHILDREN'S HOSP OF PHILADELPHIA · PI VERONIQUE M LEFEBVRE · 2022 to 2026
$2.9M
NIAMS NIH HHS R01 AR072649NIAMS NIH HHS R01 AR080062
6 · The paper itself

Abstract

SOX8 was linked in a genome-wide association study to human height heritability, but roles in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 remain unknown. We undertook here to fill this knowledge gap. High-throughput assays demonstrate expression of human

Indexed as

ChondrocytesGenome-Wide Association StudyAnimalsCell DifferentiationCell ProliferationGene Expression RegulationHumansMiceSOX9 Transcription FactorSOXE Transcription FactorsSOX8 protein, humanSOX9 protein, humanSOX9 Transcription FactorSOXE Transcription Factorsdevelopmentgrowth plate cartilagemouse modelskeletal growthSOX9

Identifiers

PMID38346197
PMCPMC10895259
OpenAlexW4391757158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.