Evidence map›Paper›PMID 38346162›Full record

ArticleeLife2024

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.

Pengfei Guo, Rebecca C Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  8. DynamicJournal of the American Chemical Society · 2025
    Article
  9. Epigenetic control and manipulation of neuronal maturation timing.Current opinion in genetics & development · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pengfei GuoDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, United States.ORCID https://orcid.org/0000-0001-6734-6549
Rebecca C LimDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, United States.
Keshari RajawasamDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, United States.
Tiffany TrinhDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, United States.
Hong SunDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, United States.
Hui ZhangDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, United States.ORCID https://orcid.org/0000-0001-6028-2554
University of Nevada, Las Vegas · US

Funding

Supplement: Regulation of SOX Proteins by Methylation-dependent Proteolysis in Stem Cells and DevelopmentR01GM140185 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI ZHANG, HUI · 2021 to 2024
$1.2M
Novel Regulation of the Activation and Assembly of the Heterimeric Receptor Tyrosine Kinase Complexes for Cell SignalingR15CA254827 · NCI · UNIVERSITY OF NEVADA LAS VEGAS · PI SUN, HONG · 2020 to 2020
$437k
NCI NIH HHS R15 CA254827NIGMS NIH HHS R01 GM140185NIH HHS R01GM140185NIH HHS R15CA254827
6 · The paper itself

Abstract

The Polycomb Repressive Complex 2 (PRC2) methylates H3K27 to regulate development and cell fate by transcriptional silencing. Alteration of PRC2 is associated with various cancers. Here, we show that mouse

Indexed as

DNA-Binding ProteinsHistonesAnimalsEnhancer of Zeste Homolog 2 ProteinHematopoiesisMethylationMicePhosphorylationPolycomb Repressive Complex 2Proto-Oncogene Proteins c-aktDNA-Binding ProteinsEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHistonesPolycomb Repressive Complex 2Proto-Oncogene Proteins c-aktAKTbiochemistrycancer biologychemical biologyCRL4DCAF5EZH2KDM1AL3MBTL3mousePRC2SET7

Identifiers

PMID38346162
PMCPMC10901513
OpenAlexW4391741703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.