ArticleeLife2024
Hippocampome.org 2.0 is a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform.Scientific reports · 2026Article
- Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025Article
- Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins.Nature communications · 2025Article
- Organization and Community Usage of a Neuron Type Circuitry Knowledge Base of the Hippocampal Formation.Biomedicines · 2025Article
- Hippocampal architecture viewed through the eyes of methodological development.Anatomical science international · 2025Review
- Biologically-informed excitatory and inhibitory ratio for robust spiking neural network training.Scientific reports · 2025Article
- Cell-type-specific contributions to theta-gamma coupled rhythms in the hippocampus.Network neuroscience (Cambridge, Mass.) · 2025Article
- Gather your neurons and model together: Community times ahead.PLoS biology · 2024Article
- Formation and retrieval of cell assemblies in a biologically realistic spiking neural network model of area CA3 in the mouse hippocampus.Journal of computational neuroscience · 2024Article
- A Continuous Attractor Model with Realistic Neural and Synaptic Properties Quantitatively Reproduces Grid Cell Physiology.International journal of molecular sciences · 2024Article
- A Continuous Attractor Model with Realistic Neural and Synaptic Properties Quantitatively Reproduces Grid Cell Physiology.bioRxiv : the preprint server for biology · 2024Article
- Formation and Retrieval of Cell Assemblies in a Biologically Realistic Spiking Neural Network Model of Area CA3 in the Mouse Hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Building a mathematical model of the brain.eLife · 2024Article
- Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.PloS one · 2024Article
- Biophysical modulation and robustness of itinerant complexity in neuronal networks.Frontiers in network physiology · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hippocampome.org is a mature open-access knowledge base of the rodent hippocampal formation focusing on neuron types and their properties. Previously, Hippocampome.org v1.0 established a foundational classification system identifying 122 hippocampal neuron types based on their axonal and dendritic morphologies, main neurotransmitter, membrane biophysics, and molecular expression (Wheeler et al., 2015). Releases v1.1 through v1.12 furthered the aggregation of literature-mined data, including among others neuron counts, spiking patterns, synaptic physiology, in vivo firing phases, and connection probabilities. Those additional properties increased the online information content of this public resource over 100-fold, enabling numerous independent discoveries by the scientific community. Hippocampome.org v2.0, introduced here, besides incorporating over 50 new neuron types, now recenters its focus on extending the functionality to build real-scale, biologically detailed, data-driven computational simulations. In all cases, the freely downloadable model parameters are directly linked to the specific peer-reviewed empirical evidence from which they were derived. Possible research applications include quantitative, multiscale analyses of circuit connectivity and spiking neural network simulations of activity dynamics. These advances can help generate precise, experimentally testable hypotheses and shed light on the neural mechanisms underlying associative memory and spatial navigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.