Evidence map›Paper›PMID 38345534›Full record

ArticleThe Journal of physiology2024

Role of paraoxonase 3 in regulating ENaC-mediated Na

Stephanie M Mutchler, Sarah Christine M Whelan, Allison Marciszyn, Jingxin Chen, Thomas R Kleyman, Shujie Shi

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. The Paraoxonase (International journal of molecular sciences · 2025
    Review
  2. Article
  3. Paraoxonase 3 regulates the pore-forming α subunit of the large-conductance KBiochimica et biophysica acta. Molecular cell research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephanie M MutchlerDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4288-4452
Sarah Christine M WhelanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Allison MarciszynDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jingxin ChenDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-2413-5415
Shujie ShiDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-3785-853X
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
T32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3M
Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas R Kleyman · 2023 to 2026
$4.8M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
The Role of The Proximal Nephron In Salt-Sensitive HypertensionR01HL128053 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GARVIN, JEFFREY L. · 2016 to 2024
$4.3M
Regulation of ENaC Trafficking and Activity in the KidneyR01DK111380 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI PALMER, LAWRENCE G · 2017 to 2025
$3.1M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
Role of piezo channels in intercalated cellsR01DK129285 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R, SATLIN, LISA M. · 2022 to 2025
$2.3M
Role of PON3 in regulating renal Na+ and K+ homeostasisR01DK130901 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2021 to 2025
$1.6M
Leica Stellaris Confocal for Kidney Imaging CoreS10OD028596 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2021
$596k
Regulation of ENaC expression by paraoxonase-2R03DK119752 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2019 to 2020
$235k
NCI NIH HHS P30 CA047904NHLBI NIH HHS R01 HL128053NHLBI NIH HHS R01 HL147818NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK111380NIDDK NIH HHS R01 DK129285NIDDK NIH HHS R01 DK130901NIDDK NIH HHS R03 DK119752NIDDK NIH HHS T32 DK007052NIDDK NIH HHS T32 DK061296NIDDK NIH HHS U54 DK137329NIH HHS S10 OD028596
6 · The paper itself

Abstract

Paraoxonase 3 (PON3) is expressed in the aldosterone-sensitive distal nephron, where filtered Na

Indexed as

AmilorideSymportersAldosteroneAnimalsAryldialkylphosphataseEpithelial Sodium ChannelsMiceNephronsSodiumSodium ChlorideAldosteroneAmilorideAryldialkylphosphataseEpithelial Sodium ChannelsSodiumSodium ChlorideSymporterschaperoneENaCkidneyPON3potassiumsodiumtransport

Identifiers

PMID38345534
PMCPMC10940207
OpenAlexW4391745306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.