Evidence map›Paper›PMID 38345299›Full record

ArticleDevelopment (Cambridge, England)2024

ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila.

Baosheng Zeng, Elizabeth M Knapp, Ekaterina Skaritanov, Rebecca Oramas, Jianjun Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. ETS‑1/ETS‑2 transcription factors in CVD (Review).International journal of molecular medicine · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Baosheng ZengDepartment of Physiology & Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Elizabeth M KnappDepartment of Physiology & Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Ekaterina SkaritanovDepartment of Physiology & Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Rebecca OramasDepartment of Physiology & Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Jianjun SunDepartment of Physiology & Neurobiology, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-6015-738X
University of Connecticut · US

Funding

Genetic interrogation of conserved follicular factors for matrix metalloproteinase regulation and ovulationR01HD086175 · NICHD · UNIVERSITY OF CONNECTICUT STORRS · PI SUN, JIANJUN · 2016 to 2020
$1.7M
Physiological Functions of Female Reproductive Tract SecretionsR01HD097206 · NICHD · UNIVERSITY OF CONNECTICUT STORRS · PI SUN, JIANJUN · 2020 to 2025
$1.6M
Leica TCS SP8 FSU AOBS 405 UV Spectral Confocal MicroscopeS10OD016435 · OD · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2014 to 2014
$456k
NICHD NIH HHS R01 HD086175NICHD NIH HHS R01 HD097206NIH HHS S10 OD016435NIH HHS S10OD016435
6 · The paper itself

Abstract

Drosophila matrix metalloproteinase 2 (MMP2) is specifically expressed in posterior follicle cells of stage-14 egg chambers (mature follicles) and is crucial for the breakdown of the follicular wall during ovulation, a process that is highly conserved from flies to mammals. The factors that regulate spatiotemporal expression of MMP2 in follicle cells remain unknown. Here, we demonstrate crucial roles for the ETS-family transcriptional activator Pointed (Pnt) and its endogenous repressor Yan in the regulation of MMP2 expression. We found that Pnt is expressed in posterior follicle cells and overlaps with MMP2 expression in mature follicles. Genetic analysis demonstrated that pnt is both required and sufficient for MMP2 expression in follicle cells. In addition, Yan was temporally upregulated in stage-13 follicle cells to fine-tune Pnt activity and MMP2 expression. Furthermore, we identified a 1.1 kb core enhancer that is responsible for the spatiotemporal expression of MMP2 and contains multiple pnt/yan binding motifs. Mutation of pnt/yan binding sites significantly impaired the Mmp2 enhancer activity. Our data reveal a mechanism of transcriptional regulation of Mmp2 expression in Drosophila ovulation, which could be conserved in other biological systems.

Indexed as

DrosophilaDrosophila ProteinsAnimalsDNA-Binding ProteinsFemaleMammalsMatrix Metalloproteinase 2Nerve Tissue ProteinsOvulationProto-Oncogene ProteinsProto-Oncogene Proteins c-etsSignal TransductionTranscription FactorsDNA-Binding ProteinsDrosophila ProteinsMatrix Metalloproteinase 2Nerve Tissue Proteinspnt protein, DrosophilaProto-Oncogene ProteinsProto-Oncogene Proteins c-etsTranscription FactorsEnhancerETS-family transcription factorsMMP2OvulationPointedYan

Identifiers

PMID38345299
PMCPMC10946439
OpenAlexW4391754313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.