Evidence map›Paper›PMID 38345213›Full record

ArticleBioconjugate chemistry2024

Cathepsin B Processing Is Required for the

Barbara Bernardim, João Conde, Tuuli Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes

Open access · hybridAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Barbara BernardimYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.
João CondeInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal.ORCID 0000-0001-8422-6792
Tuuli HakalaYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.ORCID 0000-0002-2075-3451
Julie B BecherYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.
Mary CanzanoYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.ORCID 0000-0003-4233-5370
Aldrin V VascoYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.ORCID 0000-0003-1539-1721
Tuomas P J KnowlesYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.
Jason CameronAlbumedix Ltd, Mabel Street, Nottingham NG2 3ED, United Kingdom.
Gonçalo J L BernardesYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.ORCID 0000-0001-6594-8917
University of Cambridge · GBUniversity of Lisbon · PTAlbumedix (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted drug delivery approaches that selectively and preferentially deliver therapeutic agents to specific tissues are of great interest for safer and more effective pharmaceutical treatments. We investigated whether cathepsin B cleavage of a valine-citrulline [VC(

Indexed as

Antineoplastic AgentsImmunoconjugatesNeoplasmsAlbuminsCathepsin BCell Line, TumorHumansInfant, NewbornPeptide HydrolasesTissue DistributionAlbuminsAntineoplastic AgentsCathepsin BImmunoconjugatesPeptide Hydrolases

Identifiers

PMID38345213
PMCPMC10885003
OpenAlexW4391754699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.