Evidence map›Paper›PMID 38345186›Full record

ArticleAdvanced healthcare materials2024

Platelet Vesicles Synergetic with Biosynthetic Cellulose Aerogels for Ultra-Fast Hemostasis and Wound Healing.

Ying Wang, Yicheng Guo, Yuqing Liu, Xiaohong Zhao, Yong Huang, Xiaorong Zhang, Xiaohong Hu, Kibret Mequanint, Gaoxing Luo, Malcolm Xing

Open access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ying WangInstitute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yicheng GuoInstitute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yuqing LiuDepartment of Mechanical Engineering, University of Manitoba, Winnipeg, R3T 2N2, Canada.
Xiaohong ZhaoInstitute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yong HuangInstitute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Xiaorong ZhangInstitute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Xiaohong HuInstitute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Kibret MequanintDepartment of Chemical and Biochemical Engineering, University of Western Ontario, London, N6A 5B9, Canada.
Gaoxing LuoInstitute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Malcolm XingDepartment of Mechanical Engineering, University of Manitoba, Winnipeg, R3T 2N2, Canada.ORCID 0000-0002-3547-0462
Army Medical University · CNUniversity of Manitoba · CAWestern University · CA

Funding

National Natural Science Foundation of China 81920108022-G.LNational Natural Science Foundation of China 82202484-Y.GNational Natural Science Foundation of China 82202485-Y.W
6 · The paper itself

Abstract

Achieving hemostasis in penetrating and irregular wounds is challenging because the hemostasis factor cannot arrive at the bleeding site, and substantial bleeding will wash away the blood clot. Since the inherently gradual nature of blood clot formation takes time, a physical barrier is needed before blood clot formation. Herein, an ultra-light and shape memory hemostatic aerogel consisting of oxidized bacterial cellulose (OBC) and platelet extracellular vesicles (pVEs) is reported. The OBC-pVEs aerogel provides a physical barrier for the bleeding site by self-expansion, absorbing the liquid from blood to concentrate platelets and clotting factors and accelerating the clot formation by activating platelets and transforming fibrinogen into fibrin. In the rat liver and tail injury models, the blood loss decreases by 73% and 59%, and the bleeding times are reduced by 55% and 62%, respectively. OBC-pVEs aerogel has also been shown to accelerate wound healing. In conclusion, this work introduces an effective tool for treating deep, non-compressible, and irregular wounds and offers valuable strategies for trauma bleeding and wound treatment.

Indexed as

Blood PlateletsGelsHemostasisWound HealingAnimalsBlood CoagulationCelluloseCellulose, OxidizedExtracellular VesiclesHemorrhageHemostaticsHumansMaleRatsRats, Sprague-DawleyCelluloseCellulose, OxidizedGelsHemostaticsfast blood absorptionfibrin formationflexible ultra‐light bacterial cellulose aerogelsPlatelet vesiclesrapid hemostasis

Identifiers

PMID38345186
PMCPMC11469313
OpenAlexW4391740544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.