Evidence map›Paper›PMID 38344918›Full record

ArticleEuropean journal of neurology2024

Ocular motor and vestibular dysfunction in central nervous system lymphoma.

Suk-Min Lee, Seo Young Choi, Jae-Hwan Choi, Eun Hye Oh, Dallah Yoo, Sun-Uk Lee, Hyo Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim, Kwang-Dong Choi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Suk-Min LeeDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Seo Young ChoiDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Jae-Hwan ChoiDepartment of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.ORCID 0000-0003-2710-5905
Eun Hye OhDepartment of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Dallah YooDepartment of Neurology, Kyung Hee University Hospital, Kyung Hee University, Seoul, South Korea.
Sun-Uk LeeDepartment of Neurology, Korea University Medical Center, Seoul, South Korea.ORCID 0000-0001-8660-7759
Hyo Jung KimResearch Administration Team, Seoul National University Bundang Hospital, Seongnam, South Korea.
Jeong-Yoon ChoiDizziness Center, Clinical Neuroscience Center, and Department of Neurology, Seoul National University Bundang Hospital, Seongnam, South Korea.ORCID 0000-0003-2159-9967
Ji-Soo KimDizziness Center, Clinical Neuroscience Center, and Department of Neurology, Seoul National University Bundang Hospital, Seongnam, South Korea.ORCID 0000-0002-1508-2024
Kwang-Dong ChoiDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.ORCID 0000-0002-9373-4710
Seoul National University Bundang Hospital · KRKorea University Medical Center · KRPusan National University Hospital · KRKyung Hee University · KRPusan National University Yangsan Hospital · KR

Funding

Pusan National University
6 · The paper itself

Abstract

background and purposeDiagnosis of lymphoma involving the central nervous system (CNS) is challenging. This study aimed to explore the abnormal vestibular and ocular motor findings in CNS lymphoma.

methodsA retrospective search of the medical records identified 30 patients with CNS lymphoma presenting ocular motor and vestibular abnormalities from four neurology clinics of university hospitals in South Korea (22 men, age range 14-81 years, mean 60.6 ± 15.2). The demographic and clinical features and the results of laboratory, radiological and pathological evaluation were analyzed.

resultsPatients presented with diplopia (13/30, 43%), vestibular symptoms (15/30, 50%) or both (2/30, 7%). In 15 patients with diplopia, abnormal ocular motor findings included ocular motor nerve palsy (n = 10, 67%), internuclear ophthalmoplegia (n = 2, 13%), external ophthalmoplegia (n = 2, 13%) and exophoria (n = 1, 7%). The vestibular abnormalities were isolated in 14 (82%) of 17 patients with vestibular symptoms and included combined unilateral peripheral and central vestibulopathy in three from lesions involving the vestibular nuclei. CNS lymphoma involved the brainstem (53%), cerebellum (33%), leptomeninges (30%), deep gray nuclei (23%) or cranial nerves (17%). Two patients showed the "double-panda" sign by involving the midbrain.

conclusionsThis study expands the clinical and radiological spectra of CNS lymphoma. Neuro-ophthalmological and neuro-otological evaluation may guide the early diagnosis of CNS lymphoma.

Indexed as

DiplopiaOcular Motility DisordersAdolescentAdultAgedAged, 80 and overCerebellumEye MovementsHumansMaleMiddle AgedParalysisRetrospective StudiesYoung AdultCNS lymphomadouble‐panda signisolated vestibular syndromeocular motor nerve palsyvestibular nucleus

Identifiers

PMID38344918
PMCPMC11235991
OpenAlexW4391753101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.