ArticleNature cardiovascular research2023
Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction.
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Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
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Who cites it
20 citing papers in PubMed, 18 citations in OpenAlex.
- Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 d of bed rest.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease.JACC. Basic to translational science · 2026Article
- Review
- Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation.Cell stem cell · 2026Article
- Construction Strategies and Advances in Bone Marrow Microphysiological Systems.International journal of molecular sciences · 2026Review
- Artery Tertiary Lymphoid Organs Establish Biological Platforms to Connect Atherosclerotic Plaques to the Brain.Current atherosclerosis reports · 2026Review
- Bone marrow adipoq-lineage cells in regulating the bone and marrow microenvironment: identities, functions, and mechanisms.Frontiers in endocrinology · 2026Review
- Acute myocardial infarction induces sex-specific, time-dependent remodeling of the gut microbiome and intestinal immune compartment in retired breeder C57BL/6N mice.Frontiers in microbiomes · 2026Article
- Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL-HIF2α-Controlled Adipocyte Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Piezo1 Upregulation in Monocyte-Derived Macrophages Impairs Post-Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Trained immunity: induction of an inflammatory memory in disease.Cell research · 2025Review
- Immunometabolism in heart failure.Nature reviews. Cardiology · 2025Review
- Haematometabolism rewiring in atherosclerotic cardiovascular disease.Nature reviews. Cardiology · 2025Review
- Functional diversity of cardiac macrophages in health and disease.Nature reviews. Cardiology · 2025Review
- Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.Circulation research · 2025Review
- Bone Marrow Niche in Cardiometabolic Disease: Mechanisms and Therapeutic Potential.Circulation research · 2025Review
- Deep imaging of LepRBone research · 2025Article
- Skeletal Site-Specific Lipid Profile and Hematopoietic Progenitors of Bone Marrow Adipose Tissue in Patients Undergoing Primary Hip Arthroplasty.Metabolites · 2025Article
- Article
- Systemic and local regulation of hematopoietic homeostasis in health and disease.Nature cardiovascular research · 2024Review
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Authors and funding
34 authors at 5 institutions in 5 countries.
Shuang ZhangCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Alexandre PaccaletCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
David RohdeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sebastian CremerCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Maarten HulsmansCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
I-Hsiu LeeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kyle MentkowskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jana GruneCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Maximilian J SchlossCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Lisa HonoldCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yi ZhengDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Miriam A BredellaDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Colleen BucklessDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Brian GhoshhajraDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Vikas ThondapuDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Anja M van der LaanDepartment of Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Jan J PiekDepartment of Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hans W M NiessenDepartment of Pathology and Cardiac Surgery, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands.
Fabio PallanteDepartment of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
Raimondo CarnevaleDepartment of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
Sara PerrottaDepartment of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
Daniela CarnevaleDepartment of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
Oriol Iborra-EgeaInstitut del Cor Germans Trias i Pujol, Barcelona, Spain.
Christian Muñoz-GuijosaInstitut del Cor Germans Trias i Pujol, Barcelona, Spain.
Carolina Galvez-MontonInstitut del Cor Germans Trias i Pujol, Barcelona, Spain.
Antoni Bayes-GenisInstitut del Cor Germans Trias i Pujol, Barcelona, Spain.
Charles VidoudezHarvard Center for Mass Spectrometry, Harvard University, Cambridge, MA, USA.
Sunia A TraugerHarvard Center for Mass Spectrometry, Harvard University, Cambridge, MA, USA.
David ScaddenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Filip K SwirskiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael A MoskowitzCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kamila NaxerovaCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · USInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESIstituto Neurologico Mediterraneo · ITAmsterdam University Medical Centers · NLIcahn School of Medicine at Mount Sinai · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MImaging organ system interfaces in ischemic heart diseaseR35HL139598 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2018 to 2024
$6.9MCardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9MSkeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KRONENBERG, HENRY M. · 2014 to 2018
$3.5MSkull marrow crosstalk with the central nervous systemR01NS108419 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSKOWITZ, MICHAEL A., NAHRENDORF, MATTHIAS · 2018 to 2022
$3.4MMacrophage heterogeneity in atrial remodelingR01HL155097 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2021 to 2025
$2.9MInterfering with the macrophage life cycle of atherosclerosisR01HL125428 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, DANIEL G, NAHRENDORF, MATTHIAS · 2017 to 2020
$1.9MNHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL125428NHLBI NIH HHS R01 HL155097NHLBI NIH HHS R35 HL139598NHLBI NIH HHS T32 HL076136NIAMS NIH HHS P30 AR066261NIDDK NIH HHS P30 DK040561NINDS NIH HHS R01 NS108419
Abstract
After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Since the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell homeostasis, metabolic cues may influence emergency myelopoiesis. Here, we show in humans and female mice that hematopoietic progenitor cells increase fatty acid metabolism after MI. Blockade of fatty acid oxidation by deleting carnitine palmitoyltransferase (
Indexed as
adipocytesbone marrowemergency hematopoiesisfatty acid oxidationlipolysisMyocardial infarction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.